Delphinidin, One of the Major Anthocyanidins, Prevents Bone Loss through the Inhibition of Excessive Osteoclastogenesis in Osteoporosis Model Mice

• Published in: PloS one Vol. 9; no. 5; p. e97177
• Main Authors: Moriwaki, Sawako, Suzuki, Keiko, Muramatsu, Masashi, Nomura, Atsushi, Inoue, Fumihide, Into, Takeshi, Yoshiko, Yuji, Niida, Shumpei
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 13.05.2014; Public Library of Science (PLoS)
• Subjects: Administration, Oral; Animal models; Animals; Anthocyanins; Anthocyanins - administration & dosage; Anthocyanins - analysis; Anthocyanins - pharmacology; Anthocyanins - therapeutic use; Berries; Bioavailability; Biocompatibility; Biology and Life Sciences; Biomedical materials; Blueberries; Blueberry Plants - chemistry; Bone density; Bone loss; Bone resorption; Bone Resorption - prevention & control; c-Fos protein; Cancer; Cell cycle; Cell Line; Dentistry; Differentiation; Female; Flavonoids; Fos protein; Fruits; Gene expression; Genomics; Geriatrics; Gerontology; Health promotion; Laboratories; Medicine and Health Sciences; Metabolism; Mice; Mice, Inbred C57BL; NF-kappa B - metabolism; NF-κB protein; NFATC Transcription Factors - metabolism; Older people; Oral administration; Osteoclastogenesis; Osteoclasts; Osteoclasts - drug effects; Osteoporosis; Osteoporosis - prevention & control; Ovariectomy; Physical Sciences; Polyphenols; Post-menopause; Proteomics; Proto-Oncogene Proteins c-fos - metabolism; Real-Time Polymerase Chain Reaction; Research and Analysis Methods; Reverse Transcriptase Polymerase Chain Reaction; Rodents; TRANCE protein; Transcription factors; Vegetables; X-Ray Microtomography; United States > US; Japan

Anthocyanins, one of the flavonoid subtypes, are a large family of water-soluble phytopigments and have a wide range of health-promoting benefits. Recently, an anthocyanin-rich compound from blueberries was reported to possess protective property against bone loss in ovariectomized (OVX) animal mode...