Common Breast Cancer Susceptibility Loci Are Associated with Triple-Negative Breast Cancer

• Published in: Cancer research (Chicago, Ill.) Vol. 71; no. 19; pp. 6240 - 6249
• Main Authors: STEVENS, Kristen N, VACHON, Celine M, GODWIN, Andrew K, AMBROSONE, Christine, WINQVIST, Robert, SCHMIDT, Marjanka K, COX, Angela, CROSS, Simon S, SAWYER, Elinor, HARTMANN, Arndt, BECKMANN, Matthias W, SCHULZ-WENDTLAND, Rüdiger, LEE, Adam M, EKICI, Arif B, TAPPER, William J, GERTY, Susan M, DURCAN, Lorraine, GRAHAM, Nikki, HEIN, Rebecca, NICKELS, Stephan, FLESCH-JANYS, Dieter, HEINZ, Judith, SINN, Hans-Peter, SLAGER, Susan, KONSTANTOPOULOU, Irene, FOSTIRA, Florentia, PECTASIDES, Dimitrios, DIMOPOULOS, Athanasios M, FOUNTZILAS, George, CLARKE, Christine L, BALLEINE, Rosemary, OLSON, Janet E, FREDERICKSEN, Zachary, DIASIO, Robert B, LESNICK, Timothy, PATHAK, Harsh, ROSS, Eric, WEAVER, Joellen, RÜDIGER, Thomas, FÖRSTI, Asta, DÜNNEBIE, Thomas, ADEMUYIWA, Foluso, KULKARNI, Swati, PYLKÄ, Katri, JUKKOLA-VUORINEN, Arja, OLSWOLD, Curtis, KO, Yon-Dschun, VAN LIMBERGEN, Erik, JANSSEN, Hilde, XIANSHU WANG, FASCHING, Peter A, MIRON, Penelope, ECCLES, Diana, CARPENTER, Jane E
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Association for Cancer Research 01.10.2011
• Subjects: Adult; Aged; Antineoplastic agents; Biological and medical sciences; Breast cancer; Breast Neoplasms - etiology; Breast Neoplasms - genetics; Breast Neoplasms - metabolism; Case-Control Studies; Chromosomes, Human, Pair 19 - genetics; Estrogen receptors; Estrogens; Female; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi; Genetic Predisposition to Disease; Gynecology. Andrology. Obstetrics; Health Sciences; Humans; Hälsovetenskap; Mammary gland diseases; Medical and Health Sciences; Medical sciences; Medicin och hälsovetenskap; Middle Aged; Pharmacology. Drug treatments; Polymorphism, Single Nucleotide; Progesterone receptors; Public Health, Global Health, Social Medicine and Epidemiology; Receptors, Estrogen - genetics; Receptors, Estrogen - metabolism; Receptors, Progesterone - genetics; Receptors, Progesterone - metabolism; Risk; Risk factors; Single-nucleotide polymorphism; Survival; Tumors; White People; Young Adult; Mammary gland diseases; Breast cancer; Breast disease; Malignant tumor; Risk factor; Cancer
• ISSN: 0008-5472; 1538-7445; 1538-7445
• DOI: 10.1158/0008-5472.CAN-11-1266

Triple-negative breast cancers are an aggressive subtype of breast cancer with poor survival, but there remains little known about the etiologic factors that promote its initiation and development. Commonly inherited breast cancer risk factors identified through genome-wide association studies display heterogeneity of effect among breast cancer subtypes as defined by the status of estrogen and progesterone receptors. In the Triple Negative Breast Cancer Consortium (TNBCC), 22 common breast cancer susceptibility variants were investigated in 2,980 Caucasian women with triple-negative breast cancer and 4,978 healthy controls. We identified six single-nucleotide polymorphisms, including rs2046210 (ESR1), rs12662670 (ESR1), rs3803662 (TOX3), rs999737 (RAD51L1), rs8170 (19p13.1), and rs8100241 (19p13.1), significantly associated with the risk of triple-negative breast cancer. Together, our results provide convincing evidence of genetic susceptibility for triple-negative breast cancer.