P300 aberration in first-episode schizophrenia patients: a meta-analysis

• Published in: PloS one Vol. 9; no. 6; p. e97794
• Main Authors: Qiu, Yao-qin, Tang, Yun-xiang, Chan, Raymond C K, Sun, Xin-yang, He, Jia
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 16.06.2014; Public Library of Science (PLoS)
• Subjects: Aberration; Biology and Life Sciences; Bipolar disorder; Case-Control Studies; Data processing; Event-related potentials; Event-Related Potentials, P300; Female; Humans; Information processing; Latency; Male; Medical ethics; Medicine and Health Sciences; Mental disorders; Meta-analysis; Patients; Physical Sciences; Psychiatric Status Rating Scales; Psychotropic drugs; Regression Analysis; Research and Analysis Methods; Schizophrenia; Schizophrenia - physiopathology; Studies
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0097794

Decreased P300 amplitude is one of the most consistent findings in patients with schizophrenia. However, whether prolonged P300 latency occurs in patients with schizophrenia, especially first-episode schizophrenia (FES) patients, remains controversial. A meta-analyses of P300 aberration in FES patients and healthy control(HC) group was conducted. The meta-regression analysis was performed using a random effects model. The pooled standardized effect size (PSES) was calculated as the division of the difference between the means of the two groups by the common standard deviation. A total of 569 FES patients and 747 HCs were included in this meta-analysis. P300 amplitude was significantly reduced (PSES = -0.83, 95% CI: -1.02-0.65, P = 0.00001) and P300 latency was delayed significantly in FES patients (PSES = -0.48, 95% CI: 0.14-0.81, P = 0.005). The meta-regression analysis showed that task difficulty was a source of heterogeneity. The meta-analysis confirms that disrupted information processing is found in FES patients, which is manifested by smaller P300 amplitude and delayed P300 latency.