Thrombosis of the inferior vena cava and malignant disease

• Published in: Thrombosis research Vol. 134; no. 3; pp. 668 - 673
• Main Authors: Kraft, Christiane, Schuettfort, Gundolf, Weil, Yvonne, Tirneci, Vanessa, Kasper, Alexander, Haberichter, Barbara, Schwonberg, Jan, Schindewolf, Marc, Lindhoff-Last, Edelgard, Linnemann, Birgit
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 01.09.2014
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Antineoplastic Agents - adverse effects; Blood Coagulation; Carcinoma, Renal Cell - blood; Carcinoma, Renal Cell - drug therapy; Carcinoma, Renal Cell - epidemiology; Carcinoma, Renal Cell - pathology; Child; Diagnostic Imaging - methods; Female; Germany - epidemiology; Hematology, Oncology and Palliative Medicine; Humans; Hypercoagulability; Inferior vena cava; Kidney Neoplasms - blood; Kidney Neoplasms - drug therapy; Kidney Neoplasms - epidemiology; Kidney Neoplasms - pathology; Male; Malignancy; Middle Aged; Neoplasm Invasiveness; Prevalence; Registries; Renal cell carcinoma; Retrospective Studies; Risk Factors; Thrombosis; Vena Cava, Inferior - pathology; Venous Thrombosis - blood; Venous Thrombosis - diagnosis; Venous Thrombosis - epidemiology; Young Adult; Germany; Hypercoagulability; Malignancy; Renal cell carcinoma; Thrombosis; Inferior vena cava
• ISSN: 0049-3848; 1879-2472
• DOI: 10.1016/j.thromres.2014.07.012

Abstract Background Inferior vena cava thrombosis (IVCT) is a rare event, and studies detailing its underlying aetiologies are scarce. Methods One hundred and forty-one IVCT patients (57% females, median age 47 years) were analysed with a focus on malignancy-related thrombosis and compared with 141 age- and sex-matched control patients with isolated lower-extremity deep vein thrombosis. Results Malignancies were more prevalent among IVCT patients compared with the control group (39% vs. 7.8%; P < 0.001). Malignancy-related IVCT more frequently involved the suprarenal and hepatic segments of the IVC and extended more often to the right atrium than IVCT did in non-cancer patients. Among IVCT patients with malignancies, renal cell carcinoma (38%) and other malignancies of the genitourinary tract (25%) were the most common tumours. Analysis of the underlying pathological mechanisms of malignancy-related thrombosis identified external compression of the IVC by tumour masses in 9 cases (16%), and progression of malignancy into the IVC (so-called “tumour thrombosis”) in 24 cases (44%). The remaining 22 cases (40%) were attributed to malignancy-related hypercoagulability and the presence of additional venous thromboembolism risk factors, such as previous surgery, immobilisation, or chemotherapy. Conclusions Malignancies substantially contribute to the risk of thrombosis involving the IVC. Tumour invasion, especially in cases of renal cell cancer and malignancy-related hypercoagulability are major triggering factors for thrombogenesis.