Echocardiographic Evaluation of Left Atrial Volume Index in Patients with Chronic Kidney Disease

• Published in: Saudi journal of kidney diseases and transplantation Vol. 31; no. 4; pp. 750 - 758
• Main Authors: Bokhari, Syed, Mansur, Abeera, Khan Assir, Muhammad, Ittifaq, Afshan, Sarwar, Shahbaz
• Format: Journal Article
• Language: English
• Published: Saudi Arabia Wolters Kluwer India Pvt. Ltd 01.07.2020; Medknow Publications and Media Pvt. Ltd; Medknow Publications & Media Pvt. Ltd; Wolters Kluwer Medknow Publications
• Subjects: Adult; Aged; Care and treatment; Chronic kidney failure; Echocardiography; Female; Heart Atria - diagnostic imaging; Humans; Kidney diseases; Male; Middle Aged; Prospective Studies; Pulmonary arteries; Renal Insufficiency, Chronic - diagnostic imaging; Renal Insufficiency, Chronic - epidemiology; Vascular diseases; Young Adult
• ISSN: 1319-2442; 2320-3838
• DOI: 10.4103/1319-2442.292308

Chronic kidney disease (CKD) patients are at high risk of developing cardio vascular disease. Left atrial volume index (LAVi) is an indicator of left ventricular diastolic dysfunction. We conducted this study to find out the correlation of LAVi and other echocardio- graphic parameters with estimated glomerular filtration rate (eGFR). We prospectively enrolled 170 individuals: 69 patients with CKD and 101 controls. Echocardiographic parameters including systolic and diastolic volumes of left ventricle, LAVi, ejection fraction (EF), pulmonary artery systolic pressure (PASP), and E/e ratio were measured in all participants. The demographic, clinical, and echocardiographic parameters were examined. From the total of 170 individuals, 69 (40.5%) patients had CKD and 101 (59.5%) had normal renal profile. There were 38 (55.07%) males in the CKD group and 71 (70.29%) in the control group. Patients with CKD had higher median LAVi [33.33 mL/m2 ± 11.71 vs. 22.54 mL/m2 ± 5.82; P < 0.001], higher median E/e ratio [10.41 ± 6.28 vs. 7.48 ± 2.28; P < 0.001], higher median PASP [42.47 ± 13.64 vs. 33.59 ± 12.51; P < 0.001], and lower median EF [52.79% ± 14.37 vs. 60.7% ± 8; P < 0.001]. There was a statistically significant negative correlation of eGFR with LAVi (r = -0.515, P < 0.001), PASP (r = -0.44, P = 0.001), and E/e ratio (r = -0.331, P = 0.001). Patients with CKD have higher LAVi, PASP, and E/e ratio and lower EF as compared to individuals without CKD. There is a significant negative correlation between eGFR and LAVi.