Adipose tissue dysfunction increases fatty liver association with pre diabetes and newly diagnosed type 2 diabetes mellitus

To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma gluc...

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Published inDiabetology and metabolic syndrome Vol. 8; no. 1; p. 73
Main Authors Jorge-Galarza, Esteban, Medina-Urrutia, Aida, Posadas-Sánchez, Rosalinda, Posadas-Romero, Carlos, Cardoso-Saldaña, Guillermo, Vargas-Alarcón, Gilberto, Caracas-Portilla, Nacú, González-Salazar, Carmen, Torres-Tamayo, Margarita, Juárez-Rojas, Juan Gabriel
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 11.11.2016
BioMed Central
BMC
Subjects
Adipose tissues
Body fat
Fatty liver
Impaired fasting glucose
Insulin resistance
Liver fat
Physiological aspects
Risk factors
Type 2 diabetes
Type 2 diabetes mellitus
Visceral fat
United States
Visceral fat
Insulin resistance
Impaired fasting glucose
Type 2 diabetes mellitus
Liver fat
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Summary:To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6-6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adipo-IR), were used as markers of adipose tissue dysfunction. Compared to NG subjects, those with IFG or nT2D had higher prevalence of FL and elevated VAT. FL was found to be independently associated with IFG and nT2D. Adipo-IR increased the association between FL and IFG [OR: 2.46 (95% I.C.: 1.73-3.49) to 5.42 (3.11-9.41)], whereas low adiponectin levels had a higher effect on the FL and nT2D association [OR: 4.26 (2.18-8.34) to 8.53 (2.96-24.55)]. Fatty liver was independently associated with IFG and nT2D. Our results indicate for the first time, that adipose tissue dysfunction increases these associations.
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ISSN:1758-5996
1758-5996
DOI:10.1186/s13098-016-0189-6