Plasmodium falciparum maturation abolishes physiologic red cell deformability

• Published in: Science (American Association for the Advancement of Science) Vol. 223; no. 4634; pp. 400 - 403
• Main Authors: Cranston, H.A, Boylan, C.W, Carroll, G.L, Sutera, S.P, Williamson, J.R
• Format: Journal Article
• Language: English
• Published: Washington, DC The American Association for the Advancement of Science 27.01.1984; American Association for the Advancement of Science
• Subjects: Analysis and chemistry; Animals; Biological and medical sciences; Biophysics; Blood; Blood chemical analysis; Blood Viscosity; Cell membranes; Cell physiology; Elasticity; Erythrocyte Membrane - physiology; erythrocytes; Erythrocytes - parasitology; Erythrocytes - physiology; Human protozoal diseases; Humans; immunity; Infections; Infectious diseases; Malaria; Malaria - blood; Malaria - parasitology; Malaria - physiopathology; Medical sciences; Parasites; Parasitic diseases; Parasitism; Pathology, Protozoa; Physiology, Host; Plasmodium falciparum; Plasmodium falciparum - physiology; Protozoal diseases; Resistance, Host; Rheology; Schizonts; Shear stress; Spleen; Spleen - physiopathology; Surface Properties; Trophozoites; Tropical medicine; Viscosity; Ripening; Red blood cell; Plasmodium falciparum; Deformability
• ISSN: 0036-8075; 1095-9203
• DOI: 10.1126/science.6362007

Plasmodium falciparum, effects of infection and parasite maturation on deformability of parasitized red cells exposed to fluid shear stress in vitro examined by means of rheoscope, red cells containing ring stages have impaired deformability at physiological shear stresses and recover their normal shape more slowly, red cells containing trophozoites or schizonts exhibit no deformation under same conditions, results provide mechanism to explain ability of spleen to remove parasitized red cells from circulation of both immune and nonimmune hosts