Evaluation of accordance of antibiotics package size with recommended treatment duration of guidelines for sore throat and urinary tract infections

• Published in: Antimicrobial resistance & infection control Vol. 8; no. 1; p. 30
• Main Authors: Rusic, Doris, Bozic, Josko, Bukic, Josipa, Seselja Perisin, Ana, Leskur, Dario, Modun, Darko, Tomic, Sinisa
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 11.02.2019; BioMed Central; BMC
• Subjects: Analysis; Anti-Bacterial Agents - standards; Anti-Bacterial Agents - therapeutic use; Antibiotic resistance; Antibiotics; Antimicrobial agents; Care and treatment; Communicable diseases; Consumption; Disease control; Drug dosages; Drug Packaging - standards; Drug Prescriptions - standards; Drug resistance; Drug Therapy - standards; Drugs; Duration of Therapy; Exports; Health aspects; Health education; Humans; Marketing; Medical wastes; Microbial drug resistance; Packaging; Patient compliance; Patient education; Pharyngitis - drug therapy; Powders (Particulate matter); Prescribing guideline; Prescription drugs; Prescription writing; Primary care; Professional associations; Public health; Sore throat; Studies; Urinary tract diseases; Urinary tract infections; Urinary Tract Infections - drug therapy; Urogenital system; Croatia; Urinary tract infections; Sore throat; Prescribing guideline; Antibiotic resistance
• ISSN: 2047-2994; 2047-2994
• DOI: 10.1186/s13756-019-0495-5

The aim of this study was to investigate whether marketed antibiotics package sizes are in accordance with treatment durations recommended in guidelines for prescribing antibiotics in sore throat and urinary tract infections. National drug database was searched with limitation to Antibacterials for systemic use. Formulations which did not have pre-specified dosage unit by the manufacturer were excluded (e.g. powders for oral solutions). The final list contained 94 drugs with 23 different active substances. This list was then cross-referenced with selected antimicrobial prescribing guidelines provided by Intersectoral Society for Antibiotic Resistance Control (ISKRA), National Institute for Health and Care Excellence (NICE) and The Infectious Diseases Society of America (IDSA). Seven packages matched ISKRA guidelines on sore throat while 16 were mismatched. Considering drug packages under reimbursement, 3 matched ISKRA guidelines and 8 were mismatched. Only 3 packages matched IDSA guidelines for comparable indications, and 18 were mismatched. When considering NICE guidelines there were 5 mismatched and only one package that was in accordance with the guidelines. ISKRA guidelines for urinary tract infections matched 23 packages and mismatched 58 packages. IDSA guidelines for urinary tract infections matched one package and were mismatched in 15 cases. One of the causes of leftover antibiotics is poor accordance of antibiotic package size with treatment recommendation duration. This should be identified as a potential target for reduction of excess antibiotics in the community. Measures that promote patient adherence to therapy and patient education should be considered essential to manage proper handling of leftover antibiotics.