Exploring the implications of distinct mutational signatures and mutation rates in aging and cancer

Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important tran...

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Bibliographic Details
Published inGenome medicine Vol. 8; no. 1; p. 30
Main Authors Fox, Edward J., Salk, Jesse J., Loeb, Lawrence A.
Format Journal Article
LanguageEnglish
Published England BioMed Central Ltd 17.03.2016
BioMed Central
Subjects
Age
Aging
Aging - genetics
Cancer
Cell Transformation, Neoplastic - genetics
Comment
Deoxyribonucleic acid
Development and progression
DNA
DNA repair
Evolution
Genetic aspects
Genome, Human
Genomes
Genomics
Genotype & phenotype
Humans
Hypotheses
Mutagenesis
Mutation
Mutation Rate
Neoplasms - genetics
Physiology
Tumorigenesis
Tumors
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Summary:Signatures of mutagenesis provide a powerful tool for dissecting the role of somatic mutations in both normal and pathological processes. Significantly, cancer genomes are dominated by mutation signatures distinct from those that accumulate in normal tissues with age, with potentially important translational implications.
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ISSN:1756-994X
1756-994X
DOI:10.1186/s13073-016-0286-z