Drift-barrier hypothesis and mutation-rate evolution

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 45; pp. 18488 - 18492
• Main Authors: Sung, Way, Ackerman, Matthew S, Miller, Samuel F, Doak, Thomas G, Lynch, Michael
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.11.2012; National Acad Sciences
• Subjects: Biological Evolution; Biological Sciences; Cell division; Cell Division - genetics; Cell lines; Chlamydomonas reinhardtii - genetics; Deoxyribonucleic acid; DNA; Entomoplasmataceae - genetics; Eukaryotes; Eukaryotic cells; Evolution; Genetic Drift; Genetic mutation; genome; Genome size; Genome Size - genetics; Genome, Bacterial - genetics; Genome, Plant - genetics; Genomes; Models, Genetic; Mutation; Mutation Rate; natural selection; Nucleotides; Population number; population size; Prokaryotes; prokaryotic cells; Reproductive Isolation; Sequencing; Species Specificity

Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is subject to evolutionary modification. Here, we report refined estimates of the mutation rate for a prokaryote with an exceptionally small genome and for a unicellular eukaryote with a large genome. Combined...