Drift-barrier hypothesis and mutation-rate evolution

• Published in: Proceedings of the National Academy of Sciences - PNAS Vol. 109; no. 45; pp. 18488 - 18492
• Main Authors: Sung, Way, Ackerman, Matthew S, Miller, Samuel F, Doak, Thomas G, Lynch, Michael
• Format: Journal Article
• Language: English
• Published: United States National Academy of Sciences 06.11.2012; National Acad Sciences
• Subjects: Biological Evolution; Biological Sciences; Cell division; Cell Division - genetics; Cell lines; Chlamydomonas reinhardtii - genetics; Deoxyribonucleic acid; DNA; Entomoplasmataceae - genetics; Eukaryotes; Eukaryotic cells; Evolution; Genetic Drift; Genetic mutation; genome; Genome size; Genome Size - genetics; Genome, Bacterial - genetics; Genome, Plant - genetics; Genomes; Models, Genetic; Mutation; Mutation Rate; natural selection; Nucleotides; Population number; population size; Prokaryotes; prokaryotic cells; Reproductive Isolation; Sequencing; Species Specificity
• ISSN: 0027-8424; 1091-6490; 1091-6490
• DOI: 10.1073/pnas.1216223109

Mutation dictates the tempo and mode of evolution, and like all traits, the mutation rate is subject to evolutionary modification. Here, we report refined estimates of the mutation rate for a prokaryote with an exceptionally small genome and for a unicellular eukaryote with a large genome. Combined with prior results, these estimates provide the basis for a potentially unifying explanation for the wide range in mutation rates that exists among organisms. Natural selection appears to reduce the mutation rate of a species to a level that scales negatively with both the effective population size (N ₑ), which imposes a drift barrier to the evolution of molecular refinements, and the genomic content of coding DNA, which is proportional to the target size for deleterious mutations. As a consequence of an expansion in genome size, some microbial eukaryotes with large N ₑ appear to have evolved mutation rates that are lower than those known to occur in prokaryotes, but multicellular eukaryotes have experienced elevations in the genome-wide deleterious mutation rate because of substantial reductions in N ₑ.