Comprehensive cytotoxicity studies of superparamagnetic iron oxide nanoparticles

• Published in: Biochemistry and biophysics reports Vol. 13; pp. 63 - 72
• Main Authors: Patil, Rakesh M., Thorat, Nanasaheb D., Shete, Prajkta B., Bedge, Poonam A., Gavde, Shambala, Joshi, Meghnad G., Tofail, Syed A.M., Bohara, Raghvendra A.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.03.2018; Elsevier
• Subjects: Biomedical applications; Cellular alteration; Review; SPIONs; Toxicity; Cellular alteration; SPIONs; Biomedical applications; Toxicity
• ISSN: 2405-5808; 2405-5808
• DOI: 10.1016/j.bbrep.2017.12.002

Recently lots of efforts have been taken to develop superparamagnetic iron oxide nanoparticles (SPIONs) for biomedical applications. So it is utmost necessary to have in depth knowledge of the toxicity occurred by this material. This article is designed in such way that it covers all the associated toxicity issues of SPIONs. It mainly emphasis on toxicity occurred at different levels including cellular alterations in the form of damage to nucleic acids due to oxidative stress and altered cellular response. In addition focus is been devoted for in vitro and in vivo toxicity of SPIONs, so that a better therapeutics can be designed. At the end the time dependent nature of toxicity and its ultimate faith inside the body is being discussed. •The review mainly concerns with the in vitro and in vivo toxicity of SPIONs.•Discusses different mechanism of toxicity of SPIONs.•It also covers time dependent nature of toxicity due to SPIONs and their ultimate fate after exposure to human body.