The inimitable kynurenic acid: The roles of different ionotropic receptors in the action of kynurenic acid at a spinal level

• Published in: Brain research bulletin Vol. 112; pp. 52 - 60
• Main Authors: Tuboly, Gabor, Tar, Lilla, Bohar, Zsuzsanna, Safrany-Fark, Arpad, Petrovszki, Zita, Kekesi, Gabriella, Vecsei, Laszlo, Pardutz, Arpad, Horvath, Gyongyi
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.03.2015
• Subjects: alpha7 Nicotinic Acetylcholine Receptor - antagonists & inhibitors; alpha7 Nicotinic Acetylcholine Receptor - metabolism; Analgesics - adverse effects; Analgesics - pharmacology; Animals; Disease Models, Animal; Dose-Response Relationship, Drug; Dyskinesia, Drug-Induced - metabolism; Glutamate receptors; Interaction; Iodoacetates; Kynurenic acid; Kynurenic Acid - adverse effects; Kynurenic Acid - pharmacology; Male; Motor Activity - drug effects; Motor Activity - physiology; Neurology; Osteoarthritis - drug therapy; Osteoarthritis - physiopathology; Pain; Pain - drug therapy; Pain - physiopathology; Rats, Wistar; Receptors, AMPA - antagonists & inhibitors; Receptors, AMPA - metabolism; Receptors, Kainic Acid - antagonists & inhibitors; Receptors, Kainic Acid - metabolism; Receptors, N-Methyl-D-Aspartate - antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate - metabolism; Spinal anesthesia; Spinal Cord - drug effects; Spinal Cord - physiopathology; Glutamate receptors; Pain; Kynurenic acid; Interaction; Spinal anesthesia
• ISSN: 0361-9230; 1873-2747
• DOI: 10.1016/j.brainresbull.2015.02.001

Highlights • Spinal KYNA caused motor impairment in an osteoarthritis-like joint pain model. • Dose-dependent antinociception was induced by spinal KYNA on the von Frey test. • AP5, MLA and NBQX neither alone nor in combination could mimic these KYNA effects. • Perineural KYNA did not influence EMG activity of whisker muscles.