Expert consensus on multidisciplinary therapy of colorectal cancer with lung metastases (2019 edition)

• Published in: Journal of hematology and oncology Vol. 12; no. 1; pp. 16 - 11
• Main Authors: Li, Jian, Yuan, Ying, Yang, Fan, Wang, Yi, Zhu, Xu, Wang, Zhenghang, Zheng, Shu, Wan, Desen, He, Jie, Wang, Jianping, Ba, Yi, Bai, Chunmei, Bai, Li, Bai, Wei, Bi, Feng, Cai, Kaican, Cai, Muyan, Cai, Sanjun, Chen, Gong, Chen, Keneng, Chen, Lin, Chen, Pengju, Chi, Pan, Dai, Guanghai, Deng, Yanhong, Ding, Kefeng, Fan, Qingxia, Fang, Weijia, Fang, Xuedong, Feng, Fengyi, Fu, Chuangang, Fu, Qihan, Gu, Yanhong, He, Yulong, Jia, Baoqing, Jiang, Kewei, Lai, Maode, Lan, Ping, Li, Enxiao, Li, Dechuan, Li, Jin, Li, Leping, Li, Ming, Li, Shaolei, Li, Yexiong, Li, Yongheng, Li, Zhongwu, Liang, Xiaobo, Liang, Zhiyong, Lin, Feng, Lin, Guole, Liu, Hongjun, Liu, Jianzhong, Liu, Tianshu, Liu, Yunpeng, Pan, Hongming, Pan, Zhizhong, Pei, Haiping, Qiu, Meng, Qu, Xiujuan, Ren, Li, Shen, Zhanlong, Sheng, Weiqi, Song, Chun, Song, Lijie, Sun, Jianguo, Sun, Lingyu, Sun, Yingshi, Tang, Yuan, Tao, Min, Wang, Chang, Wang, Haijiang, Wang, Jun, Wang, Shubin, Wang, Xicheng, Wang, Xishan, Wang, Ziqiang, Wu, Aiwen, Wu, Nan, Xia, Lijian, Xiao, Yi, Xing, Baocai, Xiong, Bin, Xu, Jianmin, Xu, Jianming, Xu, Nong, Xu, Ruihua, Xu, Zhongfa, Yang, Yue, Yao, Hongwei, Ye, Yingjiang, Yu, Yonghua, Yu, Yueming, Yue, Jinbo, Zhang, Jingdong, Zhang, Jun, Zhang, Suzhan, Zhang, Wei, Zhang, Yanqiao, Zhang, Zhen
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.02.2019; BioMed Central; BMC
• Subjects: Cancer metastasis; Cancer therapies; Cancer treatment; Care and treatment; China; China - epidemiology; Clinical trials; Colon cancer; Colorectal cancer; Colorectal carcinoma; Colorectal Neoplasms - drug therapy; Colorectal Neoplasms - epidemiology; Colorectal Neoplasms - surgery; Combined Modality Therapy; Comparative analysis; Consensus; Development and progression; Diagnosis, Differential; Differential diagnosis; Genetic aspects; Health aspects; Hematology; Humans; Incidence; Liver; Liver cancer; Lung cancer; Lung metastases; Lung Neoplasms - drug therapy; Lung Neoplasms - epidemiology; Lung Neoplasms - secondary; Lung Neoplasms - surgery; Lungs; Medical prognosis; Metastases; Metastasis; Multidisciplinary therapy; Oncology; Palliative Care; Practice Guidelines as Topic; Radiation therapy; Rectum; Review; Systematic review; Tomography, X-Ray Computed; Tumors; China; United States > US; Lung metastases; China; Consensus; Colorectal cancer; Multidisciplinary therapy
• ISSN: 1756-8722; 1756-8722
• DOI: 10.1186/s13045-019-0702-0

The lungs are the second most common site of metastasis for colorectal cancer (CRC) after the liver. Rectal cancer is associated with a higher incidence of lung metastases compared to colon cancer. In China, the proportion of rectal cancer cases is around 50%, much higher than that in Western countries (nearly 30%). However, there is no available consensus or guideline focusing on CRC with lung metastases. We conducted an extensive discussion and reached a consensus of management for lung metastases in CRC based on current research reports and the experts' clinical experiences and knowledge. This consensus provided detailed approaches of diagnosis and differential diagnosis and provided general guidelines for multidisciplinary therapy (MDT) of lung metastases. We also focused on recommendations of MDT management of synchronous lung metastases and initial metachronous lung metastases. This consensus might improve clinical practice of CRC with lung metastases in China and will encourage oncologists to conduct more clinical trials to obtain high-level evidences about managing lung metastases.