Discovery, characterization and potential roles of a novel NF-YAx splice variant in human neuroblastoma

• Published in: Journal of experimental & clinical cancer research Vol. 38; no. 1; pp. 482 - 25
• Main Authors: Cappabianca, Lucia, Farina, Antonietta Rosella, Di Marcotullio, Lucia, Infante, Paola, De Simone, Daniele, Sebastiano, Michela, Mackay, Andrew Reay
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 05.12.2019; BioMed Central; BMC
• Subjects: Alternative splicing; Animals; Anthracyclines; Apoptosis; Cancer; Cancer genetics; CCAAT-Binding Factor - genetics; Cell Differentiation - genetics; Cloning; Deoxyribonucleic acid; DNA; Embryo; Embryonic development; Gene expression; Genes; Genetic aspects; Genetic research; Health aspects; Humans; KIF1Bβ; Laboratories; Medical care quality; Mice; Necroptosis; Neuroblastoma; Neuroblastoma - genetics; Neuroblastoma - pathology; NF-Y; NF-YA; Novels; Pathogenesis; Physiological aspects; Proteins; RNA Splicing; Stem cells; Transcription factors; Transcription, Genetic; Transfection; Tumors; Canada; Italy; NF-Y; Alternative splicing; Genotoxic stress; Necroptosis; NF-YA; KIF1Bβ; Neuroblastoma; Cancer stem cells

Identification of novel cancer-associated splice variants is of potential diagnostic, prognostic and therapeutic importance. NF-Y transcription factor is comprised of NF-YA, NF-YB and NF-YC subunits, binds inverted CCAAT-boxes in ≈70% of gene promoters, regulates > 1000 cancer-associated genes an...