Maternal genetic contribution to pre-pregnancy obesity, gestational weight gain, and gestational diabetes mellitus

• Published in: Diabetology and metabolic syndrome Vol. 11; no. 1; p. 37
• Main Authors: Beysel, Selvihan, Eyerci, Nilnur, Ulubay, Mustafa, Caliskan, Mustafa, Kizilgul, Muhammed, Hafızoğlu, Merve, Cakal, Erman
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 14.05.2019; BioMed Central; BMC
• Subjects: Adipose tissue; Analysis; Body mass index; Body weight; Diabetes; Diabetes mellitus; Fto gene; Genes; Genetic aspects; Genetic diversity; Genetic polymorphisms; Genotypes; Genotyping; Gestational diabetes; Gestational weight gain; Glucose; Glycosylated hemoglobin; Health aspects; Health risk assessment; HNF1a gene; Insulin; Insulin resistance; Mutation; Obesity; Overweight; Polymerase chain reaction; Polymorphisms; Pre-pregnancy obesity; Pregnancy; Pregnant women; Public health; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Type 2 diabetes; Womens health; Pre-pregnancy obesity; Gestational weight gain; Gestational diabetes; Polymorphisms
• ISSN: 1758-5996; 1758-5996
• DOI: 10.1186/s13098-019-0434-x

Pre-pregnancy obesity, gestational diabetes mellitus (GDM), and gestational weight gain (GWG) are associated with each other. This is the first study to investigate whether genetic variants were associated with having GDM, and whether genetic variants-related GDM were associated with adiposity including pre-pregnancy obesity and excessive GWG in Turkish women. Women with GDM (n = 160) and without GDM (n = 145) were included in case-controlled study. Genotyping of the gene (p.I27L rs1169288, p.98V rs1800574, p.S487N rs2464196), the gene (p.BsmI rs1544410, p.ApaI rs7975232, p.TaqI rs731236, p.FokI rs2228570), and gene (rs9939609) SNPs were performed by using RT-PCR. The AA genotype was associated with an increased risk of having GDM (AA vs. AT + TT, 24.4% vs. 12.4%, OR = 2.27, 95% CI [1.23-4.19], p = 0.007). The p.I27L GT/TT genotype was associated with increased GDM risk (GT + TT vs. GG-wild, 79.4% vs. 65.5%, OR = 2.02, 95% CI 1.21-3.38], p = 0.007). However, all gene SNPs and the p.A98V, p.S487N were not associated with having GDM (p > 0.05). The AA genotype was associated with an increased risk for pre-pregnancy overweight/obesity (OR = 1.43, 95% CI [1.25-3.4], p = 0.035), but not associated with excessive GWG after adjusting for pre-pregnancy weight (p > 0.05). Pre-pregnancy weight, weight at delivery, and GWG did not differ in both and gene carriers (p > 0.05). HOMA-IR and HbA1c were increased in both p.I27L TT and AA genotype carriers (p < 0.05). The adiposity-related gene is associated with GDM by the effect of on pre-pregnancy obesity. The diabetes-related p.I27L gene is associated with GDM by increasing insulin resistance.