肺癌驱动基因与PD-1/PD-L1信号通路相互作用在非小细胞肺癌发生发展中的研究进展

程序性死亡分子1（programmed death 1,PD-1）/程序性死亡分子1配体（programmed death 1 ligand,PD-L1）通路是免疫调节的重要通路,而这一通路在肿瘤组织中存在着异常激活,提示PD-1/PD-L1通路可能参与了肿瘤的免疫逃逸过程。肿瘤驱动基因在非小细胞肺癌（non-small cell lung cancer,NSCLC）的发生发展中发挥着重要的作用,而对于肿瘤免疫逃逸的建立同样具有潜在的作用,这提示肿瘤驱动基因通路与PD-1/PD-L1通路可能存在相互作用。本文将对目前关于PD-L1与主要的肺癌驱动基因表皮生长因子受体基因（epidermal g...

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Bibliographic Details
Published in中国肺癌杂志 Vol. 20; no. 11; pp. 781 - 786
Main Author 石岩;吕望;汪路明;胡坚
Format Journal Article
LanguageChinese
Published 浙江大学附属第一医院胸外科, 杭州,310003 2017
Subjects
程序性死亡分子1
程序性死亡分子1配体
肺癌驱动基因
肺肿瘤
肺癌驱动基因
Lung tumor driver gene
Programmed death 1
程序性死亡分子1
程序性死亡分子1配体
Programmed death 1 ligand
肺肿瘤
Lung neoplasms
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ISSN1009-3419
1999-6187
DOI10.3779/j.issn.1009-3419.2017.11.10

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Summary:程序性死亡分子1（programmed death 1,PD-1）/程序性死亡分子1配体（programmed death 1 ligand,PD-L1）通路是免疫调节的重要通路,而这一通路在肿瘤组织中存在着异常激活,提示PD-1/PD-L1通路可能参与了肿瘤的免疫逃逸过程。肿瘤驱动基因在非小细胞肺癌（non-small cell lung cancer,NSCLC）的发生发展中发挥着重要的作用,而对于肿瘤免疫逃逸的建立同样具有潜在的作用,这提示肿瘤驱动基因通路与PD-1/PD-L1通路可能存在相互作用。本文将对目前关于PD-L1与主要的肺癌驱动基因表皮生长因子受体基因（epidermal growth factor receptor,EGFR）、鼠类肉瘤病毒癌基因（Kirsten rate sarcoma viral oncogene homolog,KRAS）及棘皮微管样蛋白4-间变性淋巴瘤激酶融合基因（echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase,EML4-ALK）之间的关系及调控进行综述,总结肺癌驱动基因及PD-1/PD-L1通路相互作用在非小细胞肺癌发生发展中的作用。
Bibliography:Programmed death 1（PD-1） and programmed death 1 ligand（PD-L1） pathway is a key mechanism of immune regulation, and its abnormal activation in tumor tissues suggests that PD-1/PD-L1 pathway may participate in the regulation of tumor immune escape. Driver gene mutation which is known as a key factor in the tumorigenesis of non-small cell lung cancer（NSCLC）, was also reported to play a important role in the process of tumor immune escape. It indicates that there is an interaction between driver gene and PD-1/PD-L1 pathway. The purpose of this paper is to review the relationship between PD-1/PD-L1 pathway and lung cancer driver gene, such as epidermal growth factor receptor（EGFR）, Kirsten rate sarcoma viral oncogene homolog（KRAS） and echinoderm microtubuleassociated protein-like 4-anaplastic lymphoma kinase（EML4-ALK） and to summarize the role of lung cancer driver gene and PD-1/PD-L1 pathway interaction in the tumorigenesis and progression of NSCLC.
Yan SHI, Wang LV, Luming WANG, Jian HU （Department of Thoracic Su
ISSN:1009-3419
1999-6187
DOI:10.3779/j.issn.1009-3419.2017.11.10