诱导活化肝星状细胞凋亡主要信号通路的研究进展

肝纤维化是各种病因引起的肝脏慢性进行性的病理过程，肝纤维化时细胞外基质（ECM）合成大于降解导致ECM在肝内大量沉积。肝星状细胞（HSC）的激活、转化并产生分泌大量ECM是肝纤维化形成的关键环节。而通过诱导活化的HSC发生凋亡是逆转肝纤维化的重要手段之一。就主要的凋亡信号通路：死亡受体通路、线粒体通路、内质网通路、神经生长因子通路进行一一阐述。指出了对活化HSC的凋亡途径进行选择性的药物干预有望发挥抗肝纤维化的作用。...

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Published in临床肝胆病杂志 Vol. 30; no. 2; pp. 182 - 185
Main Author 潘圆未 平键 徐列明
Format Journal Article
LanguageChinese
Published 上海市中医临床重点实验室,上海201203 2014
上海中医药大学肝病研究所,上海201203%上海中医药大学附属曙光医院,上海201203
国家中医药管理局重点研究室(慢性肝病虚损),上海201203
肝肾疾病病证教育部重点实验室,上海201203
上海中医药大学附属曙光医院,上海201203
上海中医药大学肝病研究所,上海201203
上海市中医临床重点实验室,上海201203%上海中医药大学附属曙光医院,上海201203
Subjects
星型细胞
细胞凋亡
综述
肝硬化
星型细胞
细胞凋亡
肝硬化
review
apoptosis
综述
astrocytes
liver cirrhosis
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ISSN1001-5256
DOI10.3969/j.issn.1001-5256.2014.02.021

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Summary:肝纤维化是各种病因引起的肝脏慢性进行性的病理过程，肝纤维化时细胞外基质（ECM）合成大于降解导致ECM在肝内大量沉积。肝星状细胞（HSC）的激活、转化并产生分泌大量ECM是肝纤维化形成的关键环节。而通过诱导活化的HSC发生凋亡是逆转肝纤维化的重要手段之一。就主要的凋亡信号通路：死亡受体通路、线粒体通路、内质网通路、神经生长因子通路进行一一阐述。指出了对活化HSC的凋亡途径进行选择性的药物干预有望发挥抗肝纤维化的作用。
Bibliography:Hepatic fibrosis is a chronic progressive pathological process of the liver induced by various cases. When hepatic fibrosis devel- ops, a large amount of extracellular matrix （ECM） is deposited in the liver due to the fact that the synthesis of ECM is greater than its degradation. The key step in the development of hepatic fibrosis is the activation and transformation of hepatic stellate cells （HSC） and secretion of a large amount of ECM. One of the important means for reversing hepatic fibrosis is to induce the apoptosis of activated HSC. The main apoptotic signaling pathways, death receptor pathway, mitochondrial pathway, endoplasmic reticulum pathway, and nerve growth factor path- way, are reviewed. Selective drug intervention for the apoptotic signaling pathways of activated HSCs is expected to reverse hepatic fibrosis.
liver cirrhosis ; astrocytes ; apoptosis ; review
PAN Yuanwei, PING Jian, XU Lieming. （ Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine, Shanghai 201203,
ISSN:1001-5256
DOI:10.3969/j.issn.1001-5256.2014.02.021