基于SOX9的生物学研究及其在肝癌干细胞中的研究进展
肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box-9）除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。...
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| Published in | 中国临床医学 Vol. 23; no. 6; pp. 838 - 840 |
|---|---|
| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
第二军医大学东方肝胆外科医院肝外三科,上海,200433
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-6358 |
| DOI | 10.12025/j.issn.1008-6358.2016.20160438 |
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| Abstract | 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box-9）除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。 |
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| AbstractList | 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box-9）除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。 R735.7; 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群，具有高侵袭性、易转移性、多耐药性特点，与肿瘤复发密切相关。因此，肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box‐9）除了参与多个器官的生长发育外，还与组织纤维化及肿瘤的发生有着密切关系，尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达，并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药，因此成为肝癌潜在的预后判断指标和治疗靶点。 |
| Abstract_FL | Tumor stem cells point to the malignant subgroup of tumor tissue which have high invasiveness ,multi‐drug resistance and are more likely to migrate ,which was considered closely related to tumor recurrence .Hence ,cancer stem cells may become the target of chemical therapy in the near future .CD133 ,CD90 ,CD44 were reported as the signature of cancer stem cells in several kinds of tumors .Besides being involved into the development of several organs ,SOX9 (sex determining region Y box‐9) was reported to be closely engaged into tumor genesis and tissue fibrosis .Especially ,its high expression can be found in many sorts of tumor stem cells .SOX9 is highly expressed in hepatocellular carcinoma and it has influence on the refresh ,growth and drug resistance of the cancer stem cells through certain pathways .Therefore ,SOX9 is a potential marker to evaluate the prognosis of HCC patients and therapy target . |
| Author | 王孟超 黄罡 周伟平 |
| AuthorAffiliation | 第二军医大学东方肝胆外科医院肝外三科,上海200433 |
| AuthorAffiliation_xml | – name: 第二军医大学东方肝胆外科医院肝外三科,上海,200433 |
| Author_FL | ZHOU Wei-ping HUANG Gang WANG Meng-chao |
| Author_FL_xml | – sequence: 1 fullname: WANG Meng-chao – sequence: 2 fullname: HUANG Gang – sequence: 3 fullname: ZHOU Wei-ping |
| Author_xml | – sequence: 1 fullname: 王孟超 黄罡 周伟平 |
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| Copyright | Copyright © Wanfang Data Co. Ltd. All Rights Reserved. |
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| DOI | 10.12025/j.issn.1008-6358.2016.20160438 |
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| DocumentTitleAlternate | Research progress of SOX9 in cancer stem cell of hepatocellular carcinoma |
| DocumentTitle_FL | Research progress of SOX9 in cancer stem cell of hepatocellular carcinoma |
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| Issue | 6 |
| Keywords | SOX9 cancer stem cell 肝细胞肝癌 hepatocellular carcinoma 肿瘤干细胞 |
| Language | Chinese |
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| Notes | 31-1794/R cancer stem cell; h ep ato cellu lar carcin o m a; SOX9 W A N G M eng-chao, H U A N G G ang, Z H O U W ei-ping（D ep artm en t of H ep ato b iliary Su rg ery E l, E aste rn H ep ato b iliary S u rg ery H o sp ita l, Second M ilitary M edical U n iv ersity ,Shanghai 200433 C hina） T u m o r stem cells po in t to th e m alig n an t su b g ro u p of tu m o r tissu e w hich have hig h invasiveness？ m u ltidru g resistan ce and are m ore likely to m ig ra te, w hich w as considered closely related to tu m o r recurrence. H en ce, cancer stemcells m ay becom e th e ta rg e t of chem ical th era p y in th e n ear future. C D 133, C D 90, CD44 w ere re p o rte d as th e sig n atu re ofcancer stem cells in several kinds of tum ors. B esides being involved into th e developm ent of several o rg a n s, SOX9 （ sexd eterm ining region Y b o x -9 ） w as re p o rte d to be closely engaged into tu m o r genesis and tissu e fibrosis. E sp ecially , its h ig hex p ressio n can be found in m any so rts of tu m o r stem ce |
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| PublicationTitle | 中国临床医学 |
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| Publisher | 第二军医大学东方肝胆外科医院肝外三科,上海,200433 |
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| Snippet | 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y... R735.7; 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群，具有高侵袭性、易转移性、多耐药性特点，与肿瘤复发密切相关。因此，肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y... |
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| SubjectTerms | SOX9 肝细胞肝癌 肿瘤干细胞 |
| Title | 基于SOX9的生物学研究及其在肝癌干细胞中的研究进展 |
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