基于SOX9的生物学研究及其在肝癌干细胞中的研究进展
肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box-9）除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。...
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| Published in | 中国临床医学 Vol. 23; no. 6; pp. 838 - 840 |
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| Main Author | |
| Format | Journal Article |
| Language | Chinese |
| Published |
第二军医大学东方肝胆外科医院肝外三科,上海,200433
2016
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| Subjects | |
| Online Access | Get full text |
| ISSN | 1008-6358 |
| DOI | 10.12025/j.issn.1008-6358.2016.20160438 |
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| Summary: | 肿瘤干细胞是指在肿瘤组织中高度恶性的细胞亚群,具有高侵袭性、易转移性、多耐药性特点,与肿瘤复发密切相关。因此,肿瘤干细胞可能成为未来肿瘤治疗的靶点。目前发现的肿瘤干细胞标志物包括CD133、CD90、CD44等。SOX9（sex determining region Y box-9）除了参与多个器官的生长发育外,还与组织纤维化及肿瘤的发生有着密切关系,尤其在多种肿瘤干细胞中高表达。SOX9亦在肝癌干细胞中高表达,并通过相关信号通路影响肝癌干细胞的自我更新、增殖以及耐药,因此成为肝癌潜在的预后判断指标和治疗靶点。 |
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| Bibliography: | 31-1794/R cancer stem cell; h ep ato cellu lar carcin o m a; SOX9 W A N G M eng-chao, H U A N G G ang, Z H O U W ei-ping（D ep artm en t of H ep ato b iliary Su rg ery E l, E aste rn H ep ato b iliary S u rg ery H o sp ita l, Second M ilitary M edical U n iv ersity ,Shanghai 200433 C hina） T u m o r stem cells po in t to th e m alig n an t su b g ro u p of tu m o r tissu e w hich have hig h invasiveness？ m u ltidru g resistan ce and are m ore likely to m ig ra te, w hich w as considered closely related to tu m o r recurrence. H en ce, cancer stemcells m ay becom e th e ta rg e t of chem ical th era p y in th e n ear future. C D 133, C D 90, CD44 w ere re p o rte d as th e sig n atu re ofcancer stem cells in several kinds of tum ors. B esides being involved into th e developm ent of several o rg a n s, SOX9 （ sexd eterm ining region Y b o x -9 ） w as re p o rte d to be closely engaged into tu m o r genesis and tissu e fibrosis. E sp ecially , its h ig hex p ressio n can be found in m any so rts of tu m o r stem ce |
| ISSN: | 1008-6358 |
| DOI: | 10.12025/j.issn.1008-6358.2016.20160438 |