儿童烟雾病脑梗死影响因素分析

目的 分析儿童烟雾病（Moyamoya disease,MMD）的临床及影像学特征.方法 回顾性分析176例儿童缺血型烟雾病患者临床资料,分为脑梗死组和非梗死组.组间的特征和影像学参数采用单因素分析和多因素分析,评估脑梗死的危险因素.结果 儿童缺血型烟雾病中脑梗死好发于女童（P=0.006）.大脑前动脉（anterior cerebral artery,ACA）、大脑中动脉（middle cerebral artery,MCA）和颈内动脉（internal Carotid Artery,ICA）狭窄程度是脑梗死发生的危险因素（P＜0.001,0.014和＜0.001）.多因素分析显示颈内动脉狭...

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Bibliographic Details
Published in中国卒中杂志 Vol. 12; no. 9; pp. 817 - 821
Main Author 王佳;张东;王嵘;赵继宗
Format Journal Article
LanguageChinese
Published 国家神经系统疾病临床医学研究中心,首都医科大学附属北京天坛医院 2017
国家神经系统疾病临床医学研究中心,首都医科大学附属北京天坛医院%100050,北京 首都医科大学附属北京天坛医院神经外科%100050 北京 首都医科大学附属北京天坛医院神经外科
Subjects
儿童
影像学特征
烟雾病
脑梗死
影像学特征
Moyamoya disease
脑梗死
Ischemic stroke
烟雾病
儿童
Pediatric
Angiographic characteristics
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Summary:目的 分析儿童烟雾病（Moyamoya disease,MMD）的临床及影像学特征.方法 回顾性分析176例儿童缺血型烟雾病患者临床资料,分为脑梗死组和非梗死组.组间的特征和影像学参数采用单因素分析和多因素分析,评估脑梗死的危险因素.结果 儿童缺血型烟雾病中脑梗死好发于女童（P=0.006）.大脑前动脉（anterior cerebral artery,ACA）、大脑中动脉（middle cerebral artery,MCA）和颈内动脉（internal Carotid Artery,ICA）狭窄程度是脑梗死发生的危险因素（P＜0.001,0.014和＜0.001）.多因素分析显示颈内动脉狭窄[比值比（odds ratio,OR）6.945,95％置信区间（confidence interval,CI）1.406～34.302,P=0.017）、脉络膜后动脉代偿（OR 0.780,95％CI 0.078～0.324,P=0.000）、后交通动脉代偿（OR 3.288,95％CI 1.521～7.111,P=0.002）与脑梗死发生独立相关.结论 儿童缺血型烟雾病中,脑血管狭窄程度以及侧支循环代偿情况与脑梗死发生有关.
Bibliography:11-5434/R
Moyamoya disease;Pediatric;Ischemic stroke;Angiographic characteristics
WANG Jia, ZHANG Dong, WANG Rong, ZHAO Ji-Zong （1.Department of Neurosurgery, Beijing Tiantan Hospital Capital Medical University, 100050 Beijing, China, 2National Clinical Research Center for Neurological Diseases （NCRC-ND）, 100050 Beijing, China）
Objective To investigate the clinical and angiographic characteristics of pediatric Moyamoya disease （MMD）. Methods A restrospective analysis was conducted based on the clinical data of 176 pediatric MMD patients who were divided into cerebral infarction group and non-cerebral infarction group. Interblock characteristic and imaging parameters were used to evaluate risk factors for cerebral infarction by multivariates analysis. Results In our study, cerebral infarction was higher in girls than in boys （P=0.006）. Between the infarction group and control group, the stenosis degree of anterior cerebral artery （ACA）, middle cerebral artery （MCA） and internal carotid artery （ICA） were the risk
ISSN:1673-5765
DOI:10.3969/j.issn.1673-5765.2017.09.011