雷帕霉素对帕金森病小鼠神经保护效应的研究

目的研究雷帕霉素对帕金森病（PD）小鼠模型的神经保护效应。方法采用悬挂试验和爬杆试验检测雷帕霉素对PD小鼠运动行为障碍的改善作用,免疫组织化学检测雷帕霉素对PD小鼠黑质酪氨酸羟化酶、α-突触核蛋白表达水平的影响。结果雷帕霉素明显改善了PD小鼠运动行为缺陷,提高了酪氨酸羟化酶的表达,降低了α-突触核蛋白的表达。结论雷帕霉素对PD小鼠具有明显的神经保护效应。...

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Published in现代医药卫生 Vol. 32; no. 6; pp. 801 - 803
Main Author 瞿奇 何小亮 张云龙 王坤 张秀萍
Format Journal Article
LanguageChinese
Published 广州市第六中学,广东,510300%南方医科大学基础医学院免疫学教研室,广东广州,510515%南方医科大学基础医学院实验教学管理中心,广东广州,510515 2016
Subjects
多巴胺
帕金森病
神经元
突触蛋白类
西罗莫司
突触蛋白类
Dopamine
Synapsins
Sirolimus
神经元
Neurons
帕金森病
Parkinson disease
多巴胺
西罗莫司
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Summary:目的研究雷帕霉素对帕金森病（PD）小鼠模型的神经保护效应。方法采用悬挂试验和爬杆试验检测雷帕霉素对PD小鼠运动行为障碍的改善作用,免疫组织化学检测雷帕霉素对PD小鼠黑质酪氨酸羟化酶、α-突触核蛋白表达水平的影响。结果雷帕霉素明显改善了PD小鼠运动行为缺陷,提高了酪氨酸羟化酶的表达,降低了α-突触核蛋白的表达。结论雷帕霉素对PD小鼠具有明显的神经保护效应。
Bibliography:Objective To study the neuroprotective effects of rapamycin in Parkinson′s disease（PD） mice. Methods The suspension test and the pole-climbing test were adopted to detect the improvement effect of rapamycin on the movement disorder of PD mice. The expression of tyrosine hydroxylase and α-synuclein in the substantia nigra of PD mice were examined via immunohistochemistry. Results Rapamycin significantly improved the movement disorder of PD mice,increased the expression of tyrosine hydroxylase and decreased the expression of α-synuclein in the PD mice. Conclusion Rapamycin has the obvious neuroprotective effects in PD mice.
Parkinson disease; Dopamine; Neurons; Synapsins; Sirolimus
Qu Qi,He Xiaoliang,Zhang Yunlong,Wang Kun,Zhang Xiuping （1. Guangzhou Municipal No. 6 Middle School, Guangzhou, Guangdong 510300, China ;2. Teaching and Researching Section of Immunology, Southern Medical University, Guangzhou , Guangdong 510515, China; 3. Teaching Center of Experimental Teaching Management ,School of Basic Medical Sci
ISSN:1009-5519
DOI:10.3969/j.issn.1009-5519.2016.06.001