SARS-CoV2 evokes structural brain changes resulting in declined executive function

• Published in: PloS one Vol. 19; no. 3; p. e0298837
• Main Authors: Deuter, Daniel, Hense, Katharina, Kunkel, Kevin, Vollmayr, Johanna, Schachinger, Sebastian, Wendl, Christina, Schicho, Andreas, Fellner, Claudia, Salzberger, Bernd, Hitzenbichler, Florian, Zeller, Judith, Vielsmeier, Veronika, Dodoo-Schittko, Frank, Schmidt, Nils Ole, Rosengarth, Katharina
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 12.03.2024; Public Library of Science (PLoS)
• Subjects: Analysis; Biology and Life Sciences; Brain; COVID-19; Executive Function - physiology; Gray Matter; Health aspects; Humans; Magnetic Resonance Imaging - methods; Medicine and Health Sciences; Research and Analysis Methods; RNA, Viral; SARS-CoV-2; Social Sciences; White Matter; Germany
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0298837

Several research has underlined the multi-system character of COVID-19. Though effects on the Central Nervous System are mainly discussed as disease-specific affections due to the virus' neurotropism, no comprehensive disease model of COVID-19 exists on a neurofunctional base by now. We aimed to investigate neuroplastic grey- and white matter changes related to COVID-19 and to link these changes to neurocognitive testings leading towards a multi-dimensional disease model. Groups of acutely ill COVID-19 patients (n = 16), recovered COVID-19 patients (n = 21) and healthy controls (n = 13) were prospectively included into this study. MR-imaging included T1-weighted sequences for analysis of grey matter using voxel-based morphometry and diffusion-weighted sequences to investigate white matter tracts using probabilistic tractography. Comprehensive neurocognitive testing for verbal and non-verbal domains was performed. Alterations strongly focused on grey matter of the frontal-basal ganglia-thalamus network and temporal areas, as well as fiber tracts connecting these areas. In acute COVID-19 patients, a decline of grey matter volume was found with an accompanying diminution of white matter tracts. A decline in executive function and especially verbal fluency was found in acute patients, partially persisting in recovered. Changes in gray matter volume and white matter tracts included mainly areas involved in networks of executive control and language. Deeper understanding of these alterations is necessary especially with respect to long-term impairments, often referred to as 'Post-COVID'.