Crossing the Nuclear Envelope: Hierarchical Regulation of Nucleocytoplasmic Transport

• Published in: Science (American Association for the Advancement of Science) Vol. 318; no. 5855; pp. 1412 - 1416
• Main Authors: Terry, Laura J, Shows, Eric B, Wente, Susan R
• Format: Journal Article
• Language: English
• Published: United States American Association for the Advancement of Science 30.11.2007; The American Association for the Advancement of Science
• Subjects: Active Transport, Cell Nucleus; Animals; Binding sites; Cellular biology; cytoplasm; eukaryotic cells; Freight; Freight transport; Gene expression; Gene expression regulation; Humans; Imports; Karyopherins - metabolism; Messenger RNA; Molecular biology; Nuclear Envelope - metabolism; Nuclear Envelope - ultrastructure; Nuclear Export Signals; Nuclear Localization Signals; Nuclear membrane; Nuclear Pore - metabolism; Nuclear Pore - ultrastructure; Nuclear Pore Complex Proteins - metabolism; nucleocytoplasmic transport; Physiological regulation; Receptors; Review; RNA - metabolism; Signal transduction; Stem cells
• ISSN: 0036-8075; 1095-9203; 1095-9203
• DOI: 10.1126/science.1142204

Transport of macromolecules between the nucleus and cytoplasm is a critical cellular process for eukaryotes, and the machinery that mediates nucleocytoplasmic exchange is subject to multiple levels of control. Regulation is achieved by modulating the expression or function of single cargoes, transport receptors, or the transport channel. Each of these mechanisms has increasingly broad impacts on transport patterns and capacity, and this hierarchy of control directly affects gene expression, signal transduction, development, and disease.