Pure Red Cell Aplasia Associated with Imatinib-Treated FIP1L1-PDGFRA Positive Chronic Eosinophilic Leukemia
A 28-year-old man with marked eosinophilia is described. FIP1L1/PDGFRA mRNA showed multiple alternatively-spliced fusion transcripts. Sequencing analysis showed that the deduced DNA breakpoints were intron 10 in the FIP1L1 gene and exon 12 in the PDGFRA gene. Then, a diagnosis of chronic eosinophili...
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Published in | Internal Medicine Vol. 49; no. 12; pp. 1195 - 1200 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
Japan
The Japanese Society of Internal Medicine
01.01.2010
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Subjects | |
Online Access | Get full text |
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Summary: | A 28-year-old man with marked eosinophilia is described. FIP1L1/PDGFRA mRNA showed multiple alternatively-spliced fusion transcripts. Sequencing analysis showed that the deduced DNA breakpoints were intron 10 in the FIP1L1 gene and exon 12 in the PDGFRA gene. Then, a diagnosis of chronic eosinophilic leukemia (CEL) was made. Whereas the response to the treatments with prednisolone and hydroxyurea were unsatisfactory, treatment with imatinib showed a rapid decrease of eosinophils. The hemoglobin level also dropped and bone marrow examination showed pure red cell aplasia. Continued administration of very low dose imatinib (100 mg every 5 days) led to and maintained complete molecular remission, with good tolerability. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 ObjectType-Article-2 ObjectType-Feature-1 |
ISSN: | 0918-2918 1349-7235 1349-7235 |
DOI: | 10.2169/internalmedicine.49.3178 |