Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study

The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Lipid levels during gestation varied substanti...

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Published in	American journal of obstetrics and gynecology Vol. 201; no. 5; pp. 482.e1 - 482.e8
Main Authors	Wiznitzer, Arnon, Mayer, Amit, Novack, Victor, Sheiner, Eyal, Gilutz, Harel, Malhotra, Atul, Novack, Lena
Format	Journal Article
Language	English
Published	New York, NY Mosby, Inc 01.11.2009 Elsevier
Subjects	Adult adverse outcomes Biological and medical sciences Cholesterol - blood Cross-Sectional Studies Diabetes, Gestational - blood Diabetes, Gestational - epidemiology Diseases of mother, fetus and pregnancy Female gestation Gynecology. Andrology. Obstetrics Humans lipids Medical sciences Obstetrics and Gynecology Pre-Eclampsia - blood Pre-Eclampsia - epidemiology Pregnancy Pregnancy. Fetus. Placenta Triglycerides - blood adverse outcomes gestation lipids Pregnancy Pregnancy disorders Gynecology Preeclampsia Lipids Gestational diabetes Maternal diseases Obstetrics Pregnancy toxemia Public health
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Abstract	The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG—from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint. Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
AbstractList	The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG—from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint. Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications. Objective The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Study Design Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Results Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG—from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint. Conclusion Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications. The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.OBJECTIVEThe study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.STUDY DESIGNLipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities.Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.RESULTSLipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG-from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint.Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.CONCLUSIONLipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.
Author	Mayer, Amit Wiznitzer, Arnon Gilutz, Harel Novack, Lena Sheiner, Eyal Malhotra, Atul Novack, Victor
Author_xml	– sequence: 1 givenname: Arnon surname: Wiznitzer fullname: Wiznitzer, Arnon organization: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel – sequence: 2 givenname: Amit surname: Mayer fullname: Mayer, Amit organization: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel – sequence: 3 givenname: Victor surname: Novack fullname: Novack, Victor email: victor.novack@hcri.harvard.edu organization: Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel – sequence: 4 givenname: Eyal surname: Sheiner fullname: Sheiner, Eyal organization: Department of Obstetrics and Gynecology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel – sequence: 5 givenname: Harel surname: Gilutz fullname: Gilutz, Harel organization: Department of Cardiology, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel – sequence: 6 givenname: Atul surname: Malhotra fullname: Malhotra, Atul organization: Divisions of Pulmonary and Critical Care and Sleep Medicine, Brigham and Women's Hospital, Boston, MA – sequence: 7 givenname: Lena surname: Novack fullname: Novack, Lena organization: Faculty of Health Sciences, Soroka University Medical Center, Ben-Gurion University of the Negev, Be'er-Sheva, Israel
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Snippet	The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were... Objective The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Study Design... The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes.OBJECTIVEThe study...
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SubjectTerms	Adult adverse outcomes Biological and medical sciences Cholesterol - blood Cross-Sectional Studies Diabetes, Gestational - blood Diabetes, Gestational - epidemiology Diseases of mother, fetus and pregnancy Female gestation Gynecology. Andrology. Obstetrics Humans lipids Medical sciences Obstetrics and Gynecology Pre-Eclampsia - blood Pre-Eclampsia - epidemiology Pregnancy Pregnancy. Fetus. Placenta Triglycerides - blood
Title	Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study
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