Association of lipid levels during gestation with preeclampsia and gestational diabetes mellitus: a population-based study

• Published in: American journal of obstetrics and gynecology Vol. 201; no. 5; pp. 482.e1 - 482.e8
• Main Authors: Wiznitzer, Arnon, Mayer, Amit, Novack, Victor, Sheiner, Eyal, Gilutz, Harel, Malhotra, Atul, Novack, Lena
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.11.2009; Elsevier
• Subjects: Adult; adverse outcomes; Biological and medical sciences; Cholesterol - blood; Cross-Sectional Studies; Diabetes, Gestational - blood; Diabetes, Gestational - epidemiology; Diseases of mother, fetus and pregnancy; Female; gestation; Gynecology. Andrology. Obstetrics; Humans; lipids; Medical sciences; Obstetrics and Gynecology; Pre-Eclampsia - blood; Pre-Eclampsia - epidemiology; Pregnancy; Pregnancy. Fetus. Placenta; Triglycerides - blood; adverse outcomes; gestation; lipids; Pregnancy; Pregnancy disorders; Gynecology; Preeclampsia; Lipids; Gestational diabetes; Maternal diseases; Obstetrics; Pregnancy toxemia; Public health
• ISSN: 0002-9378; 1097-6868; 1097-6868
• DOI: 10.1016/j.ajog.2009.05.032

The study evaluates lipids profile changes during gestation in pregnancies with and without preeclampsia and/or gestational diabetes. Lipid profiles were assessed between year prior and after pregnancy in 9911 women without cardiovascular comorbidities. Lipid levels during gestation varied substantially with a nadir following conception and a peak at delivery. Compared to preconception levels total cholesterol levels increased from 164.4 mg/dL to 238.6 mg/dL and triglycerides (TGs) from 92.6 mg/dL to 238.4 mg/dL. The composite endpoint (gestational diabetes mellitus or preeclampsia) occurred in 1209 women (12.2%). Its prevalence increased with levels of TG—from 7.2% in the group with low TGs (<25th percentile adjusted for the gestational month) to 19.8% in the group with high TGs (>75th percentile), but was not associated with high-density lipoprotein levels. In multivariate analysis higher TGs levels, but not low high-density lipoprotein, were associated with the primary endpoint. Lipid levels change substantially during gestation. Abnormal levels of TGs are associated with pregnancy complications.