Odor representations in mammalian cortical circuits

Spatial and temporal activity patterns of olfactory bulb projection neurons underlie the initial representations of odors in the brain. However, olfactory perception ultimately requires the integration of olfactory bulb output in higher cortical brain regions. Recent studies reveal that odor represe...

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Bibliographic Details
Published inCurrent opinion in neurobiology Vol. 20; no. 3; pp. 328 - 331
Main Author Isaacson, Jeffry S
Format Journal Article
LanguageEnglish
Published England Elsevier Ltd 01.06.2010
Subjects
Animals
Efferent Pathways - physiology
Humans
Nerve Net - physiology
Neural Inhibition - physiology
Neurology
Odorants
Olfactory Bulb - physiology
Olfactory Pathways - physiology
Psychiatry
Smell - physiology
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Summary:Spatial and temporal activity patterns of olfactory bulb projection neurons underlie the initial representations of odors in the brain. However, olfactory perception ultimately requires the integration of olfactory bulb output in higher cortical brain regions. Recent studies reveal that odor representations are sparse and highly distributed in the rodent primary olfactory (piriform) cortex. Furthermore, odor-evoked inhibition is far more widespread and broadly tuned than excitation in piriform cortex pyramidal cells. Other recent studies highlight how olfactory sensory inputs are integrated within pyramidal cell dendrites and that feedback projections from piriform cortex to olfactory bulb interneurons are a source of synaptic plasticity.
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ISSN:0959-4388
1873-6882
DOI:10.1016/j.conb.2010.02.004