Ferret Hepatitis E Virus Infection in Japan

We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%) of the samples were positive for ferret HEV RNA. Phylogenetic analysis based on the partial ORF1 indicated that these ferret HEV strains were...

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Published inJapanese Journal of Infectious Diseases Vol. 68; no. 1; pp. 60 - 62
Main Authors Li, Tian-Cheng, Yonemitsu, Kenzo, Terada, Yutaka, Takeda, Naokazu, Takaji, Wakita, Maeda, Ken
Format Journal Article
LanguageEnglish
Published Japan National Institute of Infectious Diseases, Japanese Journal of Infectious Diseases Editorial Committee 01.01.2015
Subjects
ALT
Animals
Cluster Analysis
Feces - virology
Female
ferret hepatitis E virus
Ferrets
Genetic Variation
Genotype
Hepatitis E - epidemiology
Hepatitis E - veterinary
Hepatitis E - virology
Hepatitis E virus - isolation & purification
Hospitals, Animal
Japan - epidemiology
Male
Molecular Epidemiology
Molecular Sequence Data
pathogenicity
pet
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Sequence Analysis, DNA
Sequence Homology
Japan
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Abstract We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%) of the samples were positive for ferret HEV RNA. Phylogenetic analysis based on the partial ORF1 indicated that these ferret HEV strains were clearly separated from the Netherlands strains and were divided into 2 distinct clusters. These results suggest that ferret HEV is genetically diverse, and since ferrets are not indigenous to Japan, ferret HEV has been introduced into Japan through importation.
AbstractList We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%) of the samples were positive for ferret HEV RNA. Phylogenetic analysis based on the partial ORF1 indicated that these ferret HEV strains were clearly separated from the Netherlands strains and were divided into 2 distinct clusters. These results suggest that ferret HEV is genetically diverse, and since ferrets are not indigenous to Japan, ferret HEV has been introduced into Japan through importation.
We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%) of the samples were positive for ferret HEV RNA. Phylogenetic analysis based on the partial ORF1 indicated that these ferret HEV strains were clearly separated from the Netherlands strains and were divided into 2 distinct clusters. These results suggest that ferret HEV is genetically diverse, and since ferrets are not indigenous to Japan, ferret HEV has been introduced into Japan through importation.We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%) of the samples were positive for ferret HEV RNA. Phylogenetic analysis based on the partial ORF1 indicated that these ferret HEV strains were clearly separated from the Netherlands strains and were divided into 2 distinct clusters. These results suggest that ferret HEV is genetically diverse, and since ferrets are not indigenous to Japan, ferret HEV has been introduced into Japan through importation.
Author Terada, Yutaka
Takeda, Naokazu
Yonemitsu, Kenzo
Takaji, Wakita
Li, Tian-Cheng
Maeda, Ken
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  organization: Department of Virology II, National Institute of Infectious Diseases
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  fullname: Yonemitsu, Kenzo
  organization: Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University
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  fullname: Terada, Yutaka
  organization: Laboratory of Veterinary Microbiology, Joint Faculty of Veterinary Medicine, Yamaguchi University
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  fullname: Takeda, Naokazu
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  fullname: Takaji, Wakita
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  fullname: Maeda, Ken
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10.1016/S0140-6736(03)14025-1
10.1099/vir.0.016584-0
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References_xml – reference: 5. Tei S, Kitajima N, Takahashi K, et al. Zoonotic transmission of hepatitis E virus from deer to human beings. Lancet. 2003;362:371-3.
– reference: 1. Meng XJ, Anderson DA, Arankalle VA, et al. Hepeviridae. In: King AMQ, Adams MJ, Carstens EB, et al., editors. Virus Taxonomy. 9th Report of the ICTV. London: Elsevier/Academic Press; 2012. p. 1021-28.
– reference: 17. Li TC, Ami Y, Suzaki Y, et al. Characterization of full genome of rat hepatitis E virus strain from Vietnam. Emerg Infect Dis. 2013;19:115-8.
– reference: 13. Drexler JF, Seelen A, Corman VM, et al. Bats worldwide carry hepatitis E virus-related viruses that form a putative novel genus within the family Hepeviridae. J Virol. 2012;86:9134-47.
– reference: 7. Zhao C, Ma Z, Harrison TJ, et al. A novel genotype of hepatitis E virus prevalent among farmed rabbits in China. J Med Virol. 2009;81:1371-9.
– reference: 16. Li TC, Yoshizaki S, Ami Y, et al. Susceptibility of laboratory rats against genotypes 1, 3, 4, and rat hepatitis E viruses. Vet Microbiol. 2013;163:54-61.
– reference: 18. Johne R, Plenge-Bönig A, Hess M, et al. Detection of a novel hepatitis E-like virus in faeces of wild rats using a nested broad-spectrum RT-PCR. J Gen Virol. 2010;91:750-8.
– reference: 3. Meng XJ. Hepatitis E virus: animal reservoirs and zoonotic risk. Vet Microbiol. 2010;140:256-65.
– reference: 15. Yang T, Kataoka M, Ami Y, et al. Characterization of self-assembled virus-like particles of ferret hepatitis E virus generated by recombinant baculoviruses. J Gen Virol. 2013;94:2647-56.
– reference: 10. Krog JS, Breum SØ, Jensen TH, et al. Hepatitis E virus variant in farmed mink, Denmark. Emerg Infect Dis. 2013;19:2028-30.
– reference: 14. Li TC, Yang T, Ami Y, et al. Complete genome of hepatitis E virus from laboratory ferrets. Emerg Infect Dis. 2014;20:709-12.
– reference: 4. Li TC, Chijiwa K, Sera N, et al. Hepatitis E virus transmission from wild boar meat. Emerg Infect Dis. 2005;11:1958-60.
– reference: 6. Yamamoto H, Suzuki J, Matsuda A, et al. Hepatitis E virus outbreak in monkey facility, Japan. Emerg Infect Dis. 2012;18:2032-4.
– reference: 8. Johne R, Heckel G, Plenge-Bönig A, et al. Novel hepatitis E virus genotype in Norway rats, Germany. Emerg Infect Dis. 2010;16:1452-5.
– reference: 9. Raj VS, Smits SL, Pas SD, et al. Novel hepatitis E virus in ferrets, the Netherlands. Emerg Infect Dis. 2012;18:1369-70.
– reference: 2. Emerson SU, Purcell RH. Hepatitis E virus. Rev Med Virol. 2003;13:145-54.
– reference: 11. Lin J, Norder H, Uhlhorn H, et al. Novel hepatitis E like virus found in Swedish moose. J Gen Virol. 2014;95:557-70.
– reference: 12. Bodewes R, van der Giessen J, Haagmans BL, et al. Identification of multiple novel viruses, including a parvovirus and a hepevirus, in feces of red foxes. J Virol. 2013;87:7758-64.
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Snippet We examined 85 fecal samples from pet ferrets in 10 animal hospitals in Japan for the detection of ferret hepatitis E virus (HEV) RNA. We found that 6 (7.1%)...
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SubjectTerms ALT
Animals
Cluster Analysis
Feces - virology
Female
ferret hepatitis E virus
Ferrets
Genetic Variation
Genotype
Hepatitis E - epidemiology
Hepatitis E - veterinary
Hepatitis E - virology
Hepatitis E virus - isolation & purification
Hospitals, Animal
Japan - epidemiology
Male
Molecular Epidemiology
Molecular Sequence Data
pathogenicity
pet
Phylogeny
RNA, Viral - genetics
RNA, Viral - isolation & purification
Sequence Analysis, DNA
Sequence Homology
Title Ferret Hepatitis E Virus Infection in Japan
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