Distribution and antimicrobial susceptibility of bacteria from adults with community-acquired pneumonia or complicated skin and soft tissue infections in France: the nationwide French PREMIUM study

• Published in: Diagnostic microbiology and infectious disease Vol. 83; no. 2; pp. 175 - 182
• Main Authors: Leprince, C, Desroches, M, Emirian, A, Coutureau, C, Anais, L, Fihman, V, Soussy, C.J, Decousser, J.W
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 01.10.2015
• Subjects: Adolescent; Adult; Aged; Aged, 80 and over; Anti-Bacterial Agents - pharmacology; Bacteria - classification; Bacteria - drug effects; Bacteria - isolation & purification; Ceftaroline; Community-Acquired Infections - epidemiology; Community-Acquired Infections - microbiology; Cutaneous infection; Enterobacteriaceae; Female; France - epidemiology; Haemophilus influenzae; Humans; Infectious Disease; Internal Medicine; Lower respiratory tract infection; Male; Methicillin-resistant Staphylococcus aureus; Microbial Sensitivity Tests; Middle Aged; Pneumonia, Bacterial - epidemiology; Pneumonia, Bacterial - microbiology; Skin Diseases, Bacterial - epidemiology; Skin Diseases, Bacterial - microbiology; Soft Tissue Infections - epidemiology; Soft Tissue Infections - microbiology; Staphylococcus aureus; Young Adult; France; Ceftaroline; Methicillin-resistant Staphylococcus aureus; Lower respiratory tract infection; Cutaneous infection
• ISSN: 0732-8893; 1879-0070
• DOI: 10.1016/j.diagmicrobio.2015.06.007

Abstract The empirical therapy of community-acquired pneumonia (CAP) and complicated skin and soft tissue infections (cSSTIs) must be based on updated bacterial distribution and susceptibility data. A nationwide study consecutively collected 1288 isolates from CAP (n = 467) and cSSTIs (n = 821) from 18 French hospitals between 2012 and 2013. The MIC values of commonly used antimicrobial agents, including ceftaroline, were determined. Bacterial distribution featured Pneumococcus , Haemophilus influenzae , and Staphylococcus aureus for CAPs and S. aureus , β-hemolytic streptococci and Enterobacteriaceae for cSSTIs. Antimicrobial susceptibility testing indicated i) the sustained third-generation cephalosporins and levofloxacin activity against pneumococci and H. influenzae , ii) no methicillin-resistant Staphylococcus aureus emergence among respiratory pathogens, iii) the high in vitro activity of ceftaroline against staphylococci from cSSTIs (98.7% susceptibility), and iv) the worrisome decreasing fluoroquinolone and third-generation cephalosporin susceptibilities among Enterobacteriaceae. This laboratory-based survey depicts a contrasting situation and supports the scoring of patients for the resistant pathogen risk before empirical therapy.