Neuromodulation of Neuronal Circuits: Back to the Future

• Published in: Neuron (Cambridge, Mass.) Vol. 76; no. 1; pp. 1 - 11
• Main Author: Marder, Eve
• Format: Journal Article
• Language: English
• Published: United States Elsevier Inc 04.10.2012; Elsevier Limited
• Subjects: Animals; Behavior; Humans; Neural Pathways - physiology; Neurons; Neuropeptides; Neurotransmitter Agents - physiology

All nervous systems are subject to neuromodulation. Neuromodulators can be delivered as local hormones, as cotransmitters in projection neurons, and through the general circulation. Because neuromodulators can transform the intrinsic firing properties of circuit neurons and alter effective synaptic...