Left ventricular adaptations following short-term endurance training

• Published in: Journal of applied physiology (1985) Vol. 98; no. 2; pp. 454 - 460
• Main Authors: Goodman, Jack M, Liu, Peter P, Green, Howard J
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Am Physiological Soc 01.02.2005; American Physiological Society
• Subjects: Adaptation, Physiological - physiology; Adult; Biological and medical sciences; Blood pressure; Cardiology; Exercise; Fundamental and applied biological sciences. Psychology; Heart; Heart Ventricles - diagnostic imaging; Humans; Male; Oxygen Consumption - physiology; Physical Education and Training - methods; Physical Endurance - physiology; Radionuclide Imaging; Stroke Volume - physiology; Ventricular Function; Ventricular Function, Left - physiology; Vertebrates: cardiovascular system; Heart; Short term; Physical exercise; Human; Physical training; Functional response; endurance training; exercise; Left ventricle; radionuclide imaging; Endurance; Circulatory system; Adaptation
• ISSN: 8750-7587; 1522-1601
• DOI: 10.1152/japplphysiol.00258.2004

1 Faculty of Physical Education and Health, and 2 Toronto Hospital Network (General Division) and Heart and Stroke/Richard Lewar Centre of Excellence, University of Toronto, Toronto; and 3 Department of Kinesiology, University of Waterloo, Waterloo, Ontario, Canada Submitted 9 March 2004 ; accepted in final form 17 September 2004 This study examined the effects of short-term endurance training (ET) on the left ventricular (LV) adaptation and functional response to a series of exercise challenges with increasing intensity. Eight untrained men, with a mean age of 19.4 ± 0.5 (SE) yr, were studied before and after 6 days of ET consisting of cycling 2 h/day at 65% peak aerobic power ( O 2max ). LV ejection fraction and LV volumes were assessed by radionuclide angiography at rest and during exercise at three uninterrupted successive work rates corresponding to 53, 68, and 83% of O 2max , each lasting 20 min. ET produced a calculated plasma volume expansion of 11.4 ± 2.2% ( P < 0.05). The increase in plasma volume was accompanied by an increase in O 2max from 45.9 ± 1.9 to 49.0 ± 1.0 ml·kg –1 ·min –1 ( P < 0.01) and a decrease in maximal heart rate (197 ± 2.3 to 188 ± 1.0 beats/min; P < 0.01). Resting LV function was not changed, although there was a trend for higher stroke volumes (SVs) and improvement in the rapid filling phase of diastole ( P = 0.08). Training induced an increase in exercise SV by 10.4, 10.2, and 7% at 53, 68, and 83% O 2max , respectively ( P < 0.01). These changes were secondary to increases in end-diastolic volume, which increased significantly at each exercise work rate following training (139 ± 6 to 154 ± 6 ml at 53% O 2max , and from 136 ± 5 to 156 ± 5 ml at 83% O 2max ; P < 0.01). End-systolic volumes were unchanged after ET. A significant bradycardia was observed both at rest (decreasing 7%) and exercise (decreasing 10.4%). LV ejection fraction during exercise was increased slightly by training, reaching significance at the highest work rate, after 60 min of exercise. ( P < 0.05). Cardiac output was higher following training at the highest workload (20.8 ± 2.2 vs. 22.9 ± 3.1 l/min; P < 0.01). These data indicate that short-term training elicits rapid adaptation to the LV functional response exercise, with increases in SV being secondary to a Frank-Starling effect with minor changes in contractile performance. This produced a volume-induced bradycardia and increase in LV filling, which may be of benefit during prolonged exercise. left ventricle; exercise; endurance training; radionuclide imaging Address for reprint requests and other correspondence: J. Goodman, Faculty of Physical Education and Health, Univ. of Toronto, 55 Harbord St., Toronto, Ontario, Canada M5S 2W6 (E-mail: jack.goodman{at}utoronto.ca )