Z-BeEAM (Ibritumomab tiuxetan, Bendamustine, Etoposide, Cytarabine, Melphalan) before autologous stem cell transplantation is safe and efficient for refractory large B-cell lymphoma

• Published in: Experimental hematology & oncology Vol. 4; no. 1; p. 18
• Main Authors: Tardy, Magalie P, Gastaud, Lauris, Ojeda-Uribe, Mario, Boscagli, Annick, Caruso, Salvatore, Skaf, Richard, Gutnecht, Jean, Thyss, Antoine, Peyrade, Frédéric
• Format: Journal Article
• Language: English
• Published: England BioMed Central Ltd 04.07.2015; BioMed Central
• Subjects: Analysis; Bone marrow; Cancer; Care and treatment; Chemotherapy; Comparative analysis; Cytarabine; Drug therapy; Drug therapy, Combination; Etoposide; Hematology; Lymphoma; Medical prognosis; Medical research; Medicine, Experimental; Melphalan; Neutropenia; Non-Hodgkin's lymphomas; Patients; Short Report; Stem cells; Tomography; Transplantation; Transplants & implants; France; Z-BeEAM; Aggressive Non-Hodgkin lymphoma; Conditionning regimen; Large B cell lymphoma; Autologous stem cell transplantation
• ISSN: 2162-3619; 2162-3619
• DOI: 10.1186/s40164-015-0013-2

Refractory or relapsed large B-cells lymphoma are usually treated with a high dose chemotherapy regimen followed by an autolougous stem cells transplantation. BEAM (carmustine, etoposide, cytarabine, melphalan) or more recently Z-BEAM (ibritumomab tiuxetan and BEAM) are commonly used regimens, but recently carmustine availability became difficult. The purpose of this study was to evaluate the feasibility and the safety of replacing carmustine by bendamustine in a new Z-BeEAM regimen (ibritumomab tiuxetan, bendamustine, etoposide, cytarabine, melphalan) prior to autologous stem cell transplantation. This study was a retrospective analyze of six patients, with a median age of 60, treated by Z-BeEAM before autologous stem cell transplantation. We did not put in evidence any additional toxicities compared to conventional induction chemotherapy. The main toxicities were mucositis (3 grade III among 6 patients), gastrointestinal (2 grade III vomiting and 2 grade III diarrhea) and neutropenia (6 grade IV). Engraftment was successfully achieved for all patients. At the time of analysis of this study all patients were alive and in complete response based on the PET-CT evaluation. BeEAM plus ibritumomab tiuxetan combined regimen before autologous stem cell transplantation is feasible and safe in aggressive relapsing large B-cell lymphoma.