EVIDENCE FOR INVOLVEMENT OF LIVER ALDEHYDE OXIDASE IN REDUCTION OF NITROSAMINES TO THE CORRESPONDING HYDRAZINE

The present study shows that guinea pig and rabbit liver aldehyde oxidase in the presence of its electron donors such as aldehydes or N-heterocyclic compounds reacts as N-nitrosoreductase with N-nitroso-diphenylamine and other nitrosamines.

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Bibliographic Details
Published inChemical & pharmaceutical bulletin Vol. 31; no. 2; pp. 764 - 767
Main Authors Tatsumi, Kiyoshi, Yamada, Hiroshi, Kitamura, Shigeyuki
Format Journal Article
LanguageEnglish
Published Tokyo The Pharmaceutical Society of Japan 01.01.1983
Maruzen
Subjects
acetaldehyde diphenylhydrazone
Aldehyde Oxidase
Aldehyde Oxidoreductases - metabolism
Animals
Biological and medical sciences
Carcinogenesis, carcinogens and anticarcinogens
Chemical agents
Guinea Pigs
Hydrazines - metabolism
In Vitro Techniques
liver
Liver - enzymology
Medical sciences
nitrosamines
Nitrosamines - metabolism
Oxidation-Reduction
Rabbits
Tumors
Liver
Nitrosamine
Rodentia
Rabbit
Lagomorpha
Chemical reduction
Carcinogen
Vertebrata
Mammalia
Guinea pig
Animal
Aldehyde oxidase
Mechanism of action
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Summary:The present study shows that guinea pig and rabbit liver aldehyde oxidase in the presence of its electron donors such as aldehydes or N-heterocyclic compounds reacts as N-nitrosoreductase with N-nitroso-diphenylamine and other nitrosamines.
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0009-2363
1347-5223
DOI:10.1248/cpb.31.764