Use and perceived effectiveness of non‐analgesic medical therapies for chronic pancreatitis in the United States
Aliment Pharmacol Ther 2011; 33: 149–159 Summary Background Effectiveness of medical therapies in chronic pancreatitis has been described in small studies of selected patients. Aim To describe frequency and perceived effectiveness of non‐analgesic medical therapies in chronic pancreatitis patients...
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Published in | Alimentary pharmacology & therapeutics Vol. 33; no. 1; pp. 149 - 159 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , |
Format | Journal Article |
Language | English |
Published |
Oxford, UK
Blackwell Publishing Ltd
01.01.2011
Blackwell |
Subjects | |
Online Access | Get full text |
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Summary: | Aliment Pharmacol Ther 2011; 33: 149–159
Summary
Background Effectiveness of medical therapies in chronic pancreatitis has been described in small studies of selected patients.
Aim To describe frequency and perceived effectiveness of non‐analgesic medical therapies in chronic pancreatitis patients evaluated at US referral centres.
Methods Using data on 516 chronic pancreatitis patients enrolled prospectively in the NAPS2 Study, we evaluated how often medical therapies [pancreatic enzyme replacement therapy (PERT), vitamins/antioxidants (AO), octreotide, coeliac plexus block (CPB)] were utilized and considered useful by physicians.
Results Oral PERT was commonly used (70%), more frequently in the presence of exocrine insufficiency (EI) (88% vs. 61%, P < 0.001) and pain (74% vs. 59%, P < 0.002). On multivariable analyses, predictors of PERT usage were EI (OR 5.14, 95% CI 2.87–9.18), constant (OR 3.42, 95% CI 1.93–6.04) or intermittent pain (OR 1.98, 95% CI 1.14–3.45). Efficacy of PERT was predicted only by EI (OR 2.16, 95% CI 1.36–3.42). AO were tried less often (14%) and were more effective in idiopathic and obstructive vs. alcoholic chronic pancreatitis (25% vs. 4%, P = 0.03). Other therapies were infrequently used (CPB – 5%, octreotide – 7%) with efficacy generally <50%.
Conclusions Pancreatic enzyme replacement therapy is commonly utilized, but is considered useful in only subsets of chronic pancreatitis patients. Other medical therapies are used infrequently and have limited efficacy. |
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Bibliography: | Professor Frank Burton passed away during the final review phase of this manuscript. A full list of contributing investigators is in the Appendix. ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1 Now at Wake Forest University Health, Winston, Salem, NC A full list of contributing investigators is in the appendix. Professor Frank Burton MD passed away during the final review phase of this manuscript. |
ISSN: | 0269-2813 1365-2036 |
DOI: | 10.1111/j.1365-2036.2010.04491.x |