Evaluation of Serum Trace Element Levels and Biochemical Parameters of COVID-19 Patients According to Disease Severity

• Published in: Biological trace element research Vol. 200; no. 7; pp. 3138 - 3146
• Main Authors: Kocak, Omer Faruk, Ozgeris, Fatma Betul, Parlak, Emine, Kadıoglu, Yucel, Yuce, Neslihan, Yaman, Mehmet Emrah, Bakan, Ebubekir
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2022; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biotechnology; Coronaviruses; COVID-19; Diseases; Life Sciences; Nutrition; Oncology; Parameters; Patients; Serum; Statistical analysis; Trace elements; Zinc; COVID-19; Trace elements; Biochemical parameters; ICP-MS
• ISSN: 0163-4984; 1559-0720
• DOI: 10.1007/s12011-021-02946-1

While the COVID-19 disease progresses mildly or asymptomatically in some people, its progression is severe and symptomatic in others, and it is an issue that requires a scientific response regarding the disease. The present study includes 60 people infected with COVID-19, and the cases were divided into the following groups: asymptomatic, mild, moderate, and severe. Serum Zn, Se, and Cu levels of these groups were analyzed by ICP-MS. All measurements in the patients were compared with those of 32 healthy individuals. When the patient group is compared with the control group, the serum Zn and Se concentrations were statistically low ( p  < 0.001) in the patient group. Serum Zn level decreased significantly in 4 different patient groups compared to the control group. Although the serum Se level decreased in all four patient groups compared to the control group, the change in Se level was statistically significant only in the severe and mild patient groups. This study examined serum Zn, Se concentrations, and biochemical parameters in patients with different severity of COVID-19, compared them with healthy individuals, and revealed new targets for diagnosis and treatment by revealing those data that may be important.