Association of Source of Memory Complaints and Increased Risk of Cognitive Impairment and Cognitive Decline: A Community-Based Study

• Published in: Chinese medical journal Vol. 131; no. 8; pp. 894 - 898
• Main Authors: Qi, Xue-Mei, Gu, Lin, Tang, Hui-Dong, Chen, Sheng-Di, Ma, Jian-Fang
• Format: Journal Article
• Language: English
• Published: China Wolters Kluwer India Pvt. Ltd 20.04.2018; Medknow Publications and Media Pvt. Ltd; Lippincott Williams & Wilkins Ovid Technologies; Department of Neurology & Institute of Neurology, Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Shanghai 200025, China%Department of Rehabilitation, Shanghai Ruijin Rehabilitation Hospital, Shanghai 200023, China; Medknow Publications & Media Pvt Ltd; Wolters Kluwer
• Subjects: Age; Aged; Aged, 80 and over; Aging; Alzheimer's disease; Cognition & reasoning; Cognition - physiology; Cognitive ability; Cognitive Decline; Cognitive Impairment; Memory Complaints; Cognitive disorders; Cognitive Dysfunction - physiopathology; Complaints; Dementia; Diagnosis; Education; Female; Gender differences; Health aspects; Hospitals; Humans; Logistic Models; Male; Males; Medicine; Memory; Memory - physiology; Menopause; Middle Aged; Neurology; Neuropsychological Tests; Odds Ratio; Original; Patients; Population; Risk factors; Womens health; Memory Complaints; Cognitive Decline; Cognitive Impairment
• ISSN: 0366-6999; 2542-5641
• DOI: 10.4103/0366-6999.229904

Background: Memory complaint is common in the elderly. Recently, it was shown that self-report memory complaint was predictive of cognitive decline. This study aimed to investigate the predictive value of the source of memory complaints on the risk of cognitive impairment and cognitive decline in a community-based cohort. Methods: Data on memory complaints and cognitive function were collected among 1840 Chinese participants (aged ≥55 years old) in an urban community at baseline interview and 5-year follow-up. Incident cognitive impairment was identified based on education-adjusted Mini-Mental State Examination score. Logistic regression model was used to estimate the association between the source of memory complaints and risk of cognitive impairment conversion and cognitive decline, after adjusting for covariates. Results: A total of 1840 participants were included into this study including 1713 normal participants and 127 cognitive impairment participants in 2009. Among 1713 normal participants in 2009, 130 participants were converted to cognitive impairment after 5 years of follow-up. In 2014, 606 participants were identified as cognitive decline. Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment (odds ratio [OR] = 1.60, 95% confidence interval [CI]: 1.04-2.48) and cognitive decline (OR = 1.30, 95% CI: 1.01-1.68). Furthermore, this association was more significant in males (OR = 2.10, 95% CI: 1.04-4.24 for cognitive impairment and OR = 1.87, 95% CI: 1.20-2.99 for cognitive decline) and in higher education level (OR = 1.79, 95% CI: 1.02-3.15 for cognitive impairment and OR = 1.40, 95% CI: 1.02-1.91 for cognitive decline). Conclusions: Both self- and informant-reported memory complaints were associated with an increased risk of cognitive impairment conversion and cognitive decline, especially in persons with male gender and high educational background.