Clinical outcomes after implantation of bioprosthetic valves in adults with congenital heart disease

• Published in: International journal of cardiology congenital heart disease Vol. 21; p. 100598
• Main Authors: Hsu, Andrea R., Karnakoti, Snigdha, Abdelhalim, Ahmed T., Anderson, Jason H., Jain, C. Charles, Miranda, William R., Stephens, Elizabeth H., Dearani, Joseph A., Schaff, Hartzell V., Connolly, Heidi M., Egbe, Alexander C.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025; Elsevier
• Subjects: Bioprosthetic valve; Cardiovascular; Original; Valve replacement; Valvular heart disease; Valvular heart disease; BVD; TVR; Valve replacement; CI; MVR; HR; IQR; Bioprosthetic valve; AVR; PVR; CHD; Tricuspid valve replacement; Congenital heart disease; pulmonary valve replacement; Bioprosthetic valve dysfunction; Confidence interval; Mitral valve replacement; Interquartile range; hazard ratio; Aortic valve replacement
• ISSN: 2666-6685; 2666-6685
• DOI: 10.1016/j.ijcchd.2025.100598

Bioprosthetic valves are frequently implanted in adults with congenital heart disease (CHD), but comprehensive data on bioprosthetic valve longevity and outcomes across all valve positions are lacking. The purpose of this study was to determine the incidence and risk factors for bioprosthetic valve dysfunction (BVD) across all valve positions in adults with CHD. BVD was defined as Doppler mean gradient >40 mmHg and/or severe prosthetic/periprosthetic regurgitation for aortic or pulmonary bioprostheses, or Doppler mean gradient >10 mmHg and/or severe prosthetic/periprosthetic regurgitation for mitral or tricuspid bioprostheses. There were 1221 adults with CHD that underwent implantation of a bioprosthetic valve (age 39 ± 16 years, males 617 [51 %]). At the time of valve implantation, 755 (62 %), 325 (27 %), 176 (14 %), and 21 (1.7 %) received a bioprosthetic valve in the pulmonary, tricuspid, aortic, and mitral positions, respectively. The 10-year cumulative incidence of BVD was 28 %, 36 %, 43 %, and 68 % for pulmonary, tricuspid, aortic, and mitral bioprosthetic valves, respectively (p < 0.001). Using the pulmonary valve position as the reference group, valve position (tricuspid [HR 1.26, 95 % CI 1.09–1.58), aortic [HR 1.64, 95 % CI 1.22–1.97], mitral [HR 2.01, 95 % CI 0.83–4.05]) were associated with higher risk of BVD. Younger age was associated higher risk of BVD (HR 0.95, 95 % CI 0.86–0.98 per 5-year increment). These data support the existing evidence that left-sided bioprosthetic valves demonstrate reduced durability in young patients and should be included in counseling and clinical decision-making.