The establishment of spemann's organizer and patterning of the vertebrate embryo

Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. Thi...

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Published inNature reviews. Genetics Vol. 1; no. 3; pp. 171 - 181
Main Authors De Robertis, E. M, Larraín, J, Oelgeschläger, M, Wessely, O
Format Journal Article
LanguageEnglish
Published England Nature Publishing Group 01.12.2000
Subjects
Amino Acid Sequence
Animals
Body Patterning
Glycoproteins - chemistry
Glycoproteins - genetics
Intercellular Signaling Peptides and Proteins
Molecular Sequence Data
Sequence Homology, Amino Acid
Vertebrates - embryology
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Summary:Molecular studies have begun to unravel the sequential cell-cell signalling events that establish the dorsal-ventral, or 'back-to-belly', axis of vertebrate animals. In Xenopus and zebrafish, these events start with the movement of membrane vesicles associated with dorsal determinants. This mediates the induction of mesoderm by generating gradients of growth factors. Dorsal mesoderm then becomes a signalling centre, the Spemann's organizer, which secretes several antagonists of growth-factor signalling. Recent studies have led to new models for the regulation of cell-cell signalling during development, which may also apply to the homeostasis of adult tissues.
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ISSN:1471-0056
1471-0064
DOI:10.1038/35042039