Functional genomics in virology and antiviral drug discovery

• Published in: Trends in biotechnology (Regular ed.) Vol. 21; no. 10; pp. 452 - 457
• Main Authors: DeFilippis, Victor, Raggo, Camilo, Moses, Ashlee, Früh, Klaus
• Format: Journal Article
• Language: English
• Published: Oxford Elsevier Ltd 01.10.2003; Elsevier Science; Elsevier Limited
• Subjects: Antiviral Agents - therapeutic use; Arrays; Biological and medical sciences; Biotechnology; Deoxyribonucleic acid; DNA; Drug Design; Drug resistance; Fundamental and applied biological sciences. Psychology; Gene expression; Gene Expression Regulation, Viral; Genetic engineering; Genetic technics; Genetic Therapy - methods; Genetics; Genome, Viral; Genomes; Genomics; Genomics - methods; Genomics - trends; Insects; Methods. Procedures. Technologies; Modification of gene expression level; Oligonucleotide Array Sequence Analysis - methods; Pathogenesis; Proteins; Studies; Viral diseases; Viral infections; Viral Proteins - genetics; Virology; Virology - methods; Virology - trends; Virus Diseases - genetics; Virus Diseases - therapy; Viruses; Viruses - genetics; Viruses - metabolism; Viruses - pathogenicity; Drug; Signal transduction; Transcription; Genomics; Proteomics; Antiviral; Review; Host virus relation; Virology

Virology research and antiviral drug discovery are poised to benefit from the post-genomic revolution for three main reasons. First, viruses need the host to replicate and are therefore vulnerable to inhibition of cellular pathways. Knowledge of complete genomic sequences of both virus and host now...