Echocardiographic findings in fulminant and acute myocarditis

• Published in: Journal of the American College of Cardiology Vol. 36; no. 1; pp. 227 - 232
• Main Authors: Felker, G.Michael, Boehmer, John P, Hruban, Ralph H, Hutchins, Grover M, Kasper, Edward K, Baughman, Kenneth L, Hare, Joshua M
• Format: Journal Article
• Language: English
• Published: New York, NY Elsevier Inc 01.07.2000; Elsevier Science
• Subjects: Acute Disease; Biological and medical sciences; Biopsy; Cardiovascular system; Disease Progression; Echocardiography; Heart Rate; Humans; Investigative techniques, diagnostic techniques (general aspects); Medical sciences; Myocardial Contraction; Myocarditis - diagnostic imaging; Myocarditis - pathology; Myocarditis - physiopathology; Prognosis; Pulmonary Wedge Pressure; Ultrasonic investigative techniques; Ventricular Function, Left - physiology; LV; LVEDD; FS; DCM; Sonography; Human; Echocardiography; Prognosis; Pathophysiology; Acute; Clinical form; Cardiovascular disease; Exploration; Myocardial disease; Fulminant; Myocarditis; Functional recovery; Heart disease; Left ventricle performance; Comparative study
• ISSN: 0735-1097; 1558-3597
• DOI: 10.1016/S0735-1097(00)00690-2

OBJECTIVES We sought to use echocardiography to assess the presentation and potential for recovery of left ventricular (LV) function of patients with fulminant myocarditis compared with those with acute myocarditis. BACKGROUND The clinical course of patients with myocarditis remains poorly defined. We have previously proposed a classification that provides prognostic information in myocarditis patients. Fulminant myocarditis causes a distinct onset of illness and severe hemodynamic compromise, whereas acute myocarditis has an indistinct presentation, less severe hemodynamic compromise and a greater likelihood of progression to dilated cardiomyopathy. METHODS Echocardiography was performed at presentation and at six months to test the hypothesis that fulminant (n = 11) or acute (n = 43) myocarditis could be distinguished morphologically. RESULTS Patients with both fulminant (fractional shortening 19 ± 4%) and acute myocarditis (17 ± 7%) had LV systolic dysfunction. Patients with fulminant myocarditis had near normal LV diastolic dimensions (5.3 ± 0.9 cm) but increased septal thickness (1.2 ± 0.2 cm) at presentation, while those with acute myocarditis had increased diastolic dimensions (6.1 ± 0.8 cm, p < 0.01 vs. fulminant) but normal septal thickness (1.0 ± 0.1 cm, p = 0.01 vs. fulminant). At six months, patients with fulminant myocarditis had dramatic improvement in fractional shortening (30 ± 8%) compared with no improvement in patients with acute myocarditis (19 ± 7%, p < 0.01 for interaction between time and type of myocarditis). CONCLUSIONS Fulminant myocarditis is distinguishable from acute myocarditis by echocardiography. Patients with fulminant myocarditis exhibit a substantial improvement in ventricular function at six months compared with those with acute myocarditis. Echocardiography has value in classifying patients with myocarditis and may provide prognostic information.