Trends in mortality from pulmonary hypertension amongst population with congenital heart disease in the United States from 1999 to 2020: A CDC WONDER analysis

• Published in: International journal of cardiology congenital heart disease Vol. 21; p. 100602
• Main Authors: Khan, Allahdad, Asghar, Tehreem, Ali, Kumail Mustafa, Saeed, Muhammad, Ishtiaq, Saniya, Ashfaq, Fatima, Nasrallah, Jamil, Yumn, Laiba, Akbar, Usman Ali, Collins, Peter, Ahmed, Raheel
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01.09.2025; Elsevier
• Subjects: Cardiovascular; CDC WONDER; Congenital heart disease; Mortality; Original; Pulmonary hypertension; Congenital heart disease; Mortality; CDC WONDER; Pulmonary hypertension
• ISSN: 2666-6685; 2666-6685
• DOI: 10.1016/j.ijcchd.2025.100602

Congenital heart disease (CHD) is an umbrella term describing a variety of structural cardiac malformations at birth. CHD affects approximately 1 % of live births, generating a large adult population with these abnormalities. Pulmonary hypertension (PH) in patients with adult CHD is heterogeneous, based on the type of defect and associated conditions, but is a known cause of adverse outcome. We retrieved death certificate data from the CDC-WONDER database using ICD codes (I27.0, I27.2, I27.8, and I27.9., and Q20-26). Crude mortality rates (CMRs) and age-adjusted mortality rates (AAMRs) per 100,000 persons were calculated. Temporal trends were examined using the annual percent change (APC) and average annual percent change (AAPC) determined by Joinpoint regression. From 1999 to 2020, an overall declining pattern was observed in the mortality rate. Men and women with congenital heart disease and pulmonary hypertension in the U.S. experienced a statistically significant decline in mortality rates. In terms of races, among White individuals, the decline was the most pronounced. All four U.S. census regions experienced statistically significant declines in mortality due to pulmonary hypertension among individuals with congenital heart disease. The rate of decline was steeper in rural areas compared to urban ones. This study highlights that previously implemented targeted interventions significantly contributed to the reduction of mortality amongst patiemnts with congenital heart disease and pulmonary hypertension in the U.S. Still improvements are required in certain areas, including female gender, Hispanic or Latino, and the Northeast and West regions. [Display omitted]