Global stress response during a social stress test: Impact of alexithymia and its subfactors

• Published in: Psychoneuroendocrinology Vol. 50; pp. 53 - 61
• Main Authors: Hua, Jiewen, Le Scanff, Christine, Larue, Jacques, José, Ferreira, Martin, Jean-Claude, Devillers, Laurence, Filaire, Edith
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 01.12.2014; Elsevier
• Subjects: Adolescent; Adult; Affective Symptoms - complications; Affective Symptoms - physiopathology; Alexithymia; Alpha-amylase; Arousal - physiology; Behavioral psychophysiology; Biological and medical sciences; Chromogranin A; Chromogranin A - analysis; Cortisol; Emotions - physiology; Endocrinology & Metabolism; Female; Fundamental and applied biological sciences. Psychology; Heart rate; Heart Rate - physiology; Hormones and behavior; Humans; Hydrocortisone - analysis; Hypothalamo-Hypophyseal System - physiopathology; Male; Pituitary-Adrenal System - physiopathology; Psychiatry; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychosocial stress; Saliva; Saliva - chemistry; Salivary alpha-Amylases - analysis; Speech; Stress, Psychological - complications; Stress, Psychological - physiopathology; Young Adult; Alpha-amylase; Heart rate; Chromogranin A; Psychosocial stress; Alexithymia; Cortisol; Saliva; Corticosteroid; Amylase; Enzyme; Steroid hormone; Antiinflammatory agent; Neuropsychological test; Psychosocial factor; Hydrocortisone; Glucocorticoid; Stress; Chromogranin; Adrenal hormone; Social impact
• ISSN: 0306-4530; 1873-3360; 1873-3360
• DOI: 10.1016/j.psyneuen.2014.08.003

•We study the association between alexithymia and its subfactors with HPA and SAM activity.•Stress was induced experimentally using a public-speaking paradigm.•The increased HPA activity was related to only one alexithymia subfactor, DIFF. Alexithymia is a personality trait characterized by difficulties in identifying, describing and communicating one's own emotions. Recent studies have associated specific effects of this trait and its subfactors with hypothalamo-pituitary-adrenal (HPA) axis markers during stress. The aim of this study was to analyze the association between alexithymia and its subfactors with HPA and sympatho-adrenal medullar (SAM) activity. Stress was induced experimentally using a public-speaking paradigm. Salivary cortisol, alpha-amylase (AA), chromogranin A (CgA) and heart rate (HR) were collected during the defined periods of baseline, stress, and recovery in 19 males and 24 female healthy university students. Subjects reacted to the stressor with a significant cortisol and SAM response. Subjects scoring high on alexithymia reacted significantly more intensely than low scorers in basal anticipatory as well as peak cortisol and area under the curve. Regression analyses revealed that the increased HPA activity was related to only one alexithymia subfactor, the difficulty in differentiating feelings and distinguishing them from bodily sensations and emotion arousal. Alexithymia and its subfactors were specifically related to cortisol responses. This research should be replicated with more subjects and should take into account more parameters reflecting sympathetic and/or parasympathetic activation, as well as HPA axis. Factors such as coping strategies and the perception of the situation as a challenge have also to be explored.