Genomic imprinting: the emergence of an epigenetic paradigm

The emerging awareness of the contribution of epigenetic processes to genome function in health and disease is underpinned by decades of research in model systems. In particular, many principles of the epigenetic control of genome function have been uncovered by studies of genomic imprinting. The ph...

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Bibliographic Details
Published inNature reviews. Genetics Vol. 12; no. 8; pp. 565 - 575
Main Author Ferguson-Smith, Anne C
Format Journal Article Book Review
LanguageEnglish
Published London Nature Publishing Group 01.08.2011
Subjects
Animals
Biological and medical sciences
DNA Methylation
Embryonic development
Epigenesis, Genetic
Epigenetics
Epigenomics
Female
Females
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Regulation, Developmental
Genes
Genetic disorders
Genetics of eukaryotes. Biological and molecular evolution
Genomes
Genomic Imprinting
Histones - metabolism
Humans
Male
Methylation
RNA, Untranslated - genetics
X chromosomes
United Kingdom
Epigenetics
Review
Genomic imprinting
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Summary:The emerging awareness of the contribution of epigenetic processes to genome function in health and disease is underpinned by decades of research in model systems. In particular, many principles of the epigenetic control of genome function have been uncovered by studies of genomic imprinting. The phenomenon of genomic imprinting, which results in some genes being expressed in a parental--origin-specific manner, is essential for normal mammalian growth and development and exemplifies the regulatory influences of DNA methylation, chromatin structure and non-coding RNA. Setting seminal discoveries in this field alongside recent progress and remaining questions shows how the study of imprinting continues to enhance our understanding of the epigenetic control of genome function in other contexts.
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ISSN:1471-0056
1471-0064
DOI:10.1038/nrg3032