Salinomycin inhibits osteosarcoma by targeting its tumor stem cells

• Published in: Cancer letters Vol. 311; no. 1; pp. 113 - 121
• Main Authors: Tang, Qing-Lian, Zhao, Zhi-Qiang, Li, Jin-chun, Liang, Yi, Yin, Jun-Qiang, Zou, Chang-Ye, Xie, Xian-Biao, Zeng, Yi-Xin, Shen, Jing-Nan, Kang, Tiebang, Wang, Jin
• Format: Journal Article
• Language: English
• Published: Ireland Elsevier Ireland Ltd 01.12.2011; Elsevier Limited
• Subjects: Adolescence; Bone marrow; Bone Neoplasms - drug therapy; Bone Neoplasms - metabolism; Bone Neoplasms - pathology; Bone tumors; Cell Line, Tumor; Chemotherapy; Children; Cloning; Down-Regulation - drug effects; Drug Resistance, Neoplasm; Experiments; Hematology, Oncology and Palliative Medicine; Humans; Immunohistochemistry; Metastases; Neoplastic Stem Cells - drug effects; Neoplastic Stem Cells - metabolism; Neoplastic Stem Cells - pathology; Oct-4 protein; Octamer Transcription Factor-3 - biosynthesis; Osteosarcoma; Osteosarcoma - drug therapy; Osteosarcoma - metabolism; Osteosarcoma - pathology; Osteosarcoma cells; Overexpression; Prognosis; Proteins; Pyrans - pharmacology; Salinomycin; Side effects; Signal transduction; SOXB1 Transcription Factors - biosynthesis; Stem cells; Surgery; Tumor stem cell; Wnt protein; Wnt Signaling Pathway - drug effects; Wnt/β-catenin; Chemotherapy; Salinomycin; Osteosarcoma; Wnt/β-catenin; Tumor stem cell
• ISSN: 0304-3835; 1872-7980
• DOI: 10.1016/j.canlet.2011.07.016

Highlights ► We have utilized three different methods to enrich TSCs in osteosarcoma. ► Salinomycin could selectively target TSCs in osteosarcoma both in vitro and in vivo . ► Wnt/β-catenin signaling pathway may be involved in this inhibition of salinomycin. ► Salinomycin is an effective inhibitor of osteosarcoma stem cells.