血清FSH、LH、PRL 与浆液性卵巢癌临床病理特征及预后的关系

目的探讨血清卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)与浆液性卵巢癌临床病理特征及预后的关系。方法选择2000年1月—2015年12月在天津医科大学总医院妇产科住院治疗的浆液性卵巢癌患者73例。采用Mann-WhitneyU检验分析患者血清FSH、LH、PRL与临床病理特征的关系,采用Kaplan-Meier(K-M)分析不同临床病理特征患者生存率差异,多因素COX比例风险回归模型分析浆液性卵巢癌患者预后的影响因素。结果年龄>50岁组血清FSH、LH水平显著高于年龄≤50岁组,绝经组血清FSH、LH水平显著高于未绝经组(均P<0.05),其他不同临床...

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Published in天津医药 Vol. 45; no. 6; pp. 596 - 600
Main Author 崔蕾;郭飞;闫晔;潘明霞;董羊羊;薛凤霞
Format Journal Article
LanguageChinese
Published 天津医科大学总医院妇产科 300052 2017
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Summary:目的探讨血清卵泡刺激素(FSH)、黄体生成素(LH)、催乳素(PRL)与浆液性卵巢癌临床病理特征及预后的关系。方法选择2000年1月—2015年12月在天津医科大学总医院妇产科住院治疗的浆液性卵巢癌患者73例。采用Mann-WhitneyU检验分析患者血清FSH、LH、PRL与临床病理特征的关系,采用Kaplan-Meier(K-M)分析不同临床病理特征患者生存率差异,多因素COX比例风险回归模型分析浆液性卵巢癌患者预后的影响因素。结果年龄>50岁组血清FSH、LH水平显著高于年龄≤50岁组,绝经组血清FSH、LH水平显著高于未绝经组(均P<0.05),其他不同临床病理特征分组患者间血清FSH、LH水平差异无统计学意义;不同临床病理特征分组患者间血清PRL水平差异均无统计学意义。单因素分析显示,血清FSH水平高(>40.13IU/L)、血清PRL水平高(>14.96μg/L)、FIGO分期(Ⅲ+Ⅳ)的患者预后差(均P<0.05);血清LH水平与患者预后无关(P>0.05)。COX多因素回归分析显示,血清PRL>14.96μg/L是影响浆液性卵巢癌预后的危险因素[HR(95%CI)为3.530(1.180~10.557),P=0.024]。结论绝经后妇女血清中FSH、LH水平较绝经前显著升高,PRL与浆液性卵巢癌患者预后有关。
Bibliography:ovarian neoplasms; follicle stimulating hormone; luteinizing hormone; prolactin; prognosis; serous ovarian cancer
Objective To investigate the relationship between serum follicle stimulating hormone(FSH),luteinizinghormone(LH),prolactin(PRL)and clinicopathological features and prognosis of serous ovarian cancer retrospectively.Methods A total of73patients with serous ovarian cancer treated in the Department of Obstetrics and Gynecology ofTianjin Medical University General Hospital from January2000to December2015were included in this study.Therelationship between serum FSH,LH,PRL and clinicopathological features was analyzed by Mann-Whitney U method.Kaplan-Meier(K-M)method was used to analyze survival rates of patients with different clinical features.Multivariate Coxproportional hazards regression analysis was used to analyze prognostic factors of serous ovarian cancer patients.ResultsThe mean concentrations of serum FSH and LH were significantly higher in the>50year-old group than those in the<50year-ol
ISSN:0253-9896
DOI:10.11958/20170184