EGCG抗癌分子相关机理研究进展
表没食子儿茶素表没食子酸酯(EGCG)具有很好的抗癌活性,但其抗癌的分子机理较复杂,可通过多条途径抑制癌细胞生长或诱导癌细胞凋亡,其中较为关键的分子机理与EGCG的抗血管形成、阻滞癌细胞生长周期、抑制部分转录因子的表达以及调节细胞相关信号转导机制等有着密切的联系。综述了近年来同内外EDCG抗癌的分子机制研究进展。...
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Published in | 广东农业科学 Vol. 39; no. 23; pp. 154 - 158 |
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Main Author | |
Format | Journal Article |
Language | Chinese |
Published |
广东省农科院茶叶研究所/广东省茶树资源创新利用重点实验室,广东广州510640
2012
华南师范大学化学与环境学院,广东广州510006%华南师范大学化学与环境学院,广东广州,510006%广东省农科院茶叶研究所/广东省茶树资源创新利用重点实验室,广东广州,510640 |
Subjects | |
Online Access | Get full text |
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Summary: | 表没食子儿茶素表没食子酸酯(EGCG)具有很好的抗癌活性,但其抗癌的分子机理较复杂,可通过多条途径抑制癌细胞生长或诱导癌细胞凋亡,其中较为关键的分子机理与EGCG的抗血管形成、阻滞癌细胞生长周期、抑制部分转录因子的表达以及调节细胞相关信号转导机制等有着密切的联系。综述了近年来同内外EDCG抗癌的分子机制研究进展。 |
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Bibliography: | 44-1267/S EGCG shows good anticancer activity, and its effect and mechanism have also been a hot research topic in recent years. EGCG's anticaneer molecular mechanisms are complex. And various ways are confirmed to be available to achieve the aim of suppressing cancer cell including antiangiogenic activity, cell cycle blocking, transcription factors inhibition and signal transduction regulation.The paper reviewed the progress on anticancer molecular mechanism of EGCG. YE Xin-wei, LUO Yi-fan, PAN Shun-shun, ZENG Qiong, MIAO Ai-qing, PANG Shi, SUN Shi-li (1.Tea Research Institute,Guangdong Academy of Agricultural Sciences/Guangdong Key Laboratory of Tea Plant Resources Innovation & Utilization, Guangzhou 510640, China; 2.School of Chemistry and Environment, South China Normal University, Guangzhou 510006, China) EGCG; VEGF; cell cycle; transcription factors; signal transduetion |
ISSN: | 1004-874X |