I 2 -catalyzed synthesis of 3-aminopyrrole with homopropargylic amines and nitrosoarenes

The synthesis of 3-aminopyrrole using the amination reagent nitrosoarenes and homopropargylic amines catalyzed by I through cyclization and amination has been developed. This protocol features excellent functional group tolerance and mild reaction conditions, yielding 3-aminopyrroles in moderate to...

Full description

Saved in:
Bibliographic Details
Published inChemical communications (Cambridge, England) Vol. 60; no. 27; pp. 3701 - 3704
Main Authors Qin, Jiaze, Jiang, Shixuan, Luo, Xiaofeng, Wang, Tianqiang, Liu, Peihua, Yuan, Bingxiang, Yan, Rulong
Format Journal Article
LanguageEnglish
Published England 28.03.2024
Online AccessGet full text

Cover

More Information
Summary:The synthesis of 3-aminopyrrole using the amination reagent nitrosoarenes and homopropargylic amines catalyzed by I through cyclization and amination has been developed. This protocol features excellent functional group tolerance and mild reaction conditions, yielding 3-aminopyrroles in moderate to good yields without a metal catalyst. This method realizes the construction and amination of the 3-aminopyrroles in which nitrosoarenes serve as the amine source and oxidant.
ISSN:1359-7345
1364-548X
DOI:10.1039/D4CC00482E