Placebo and Other Interventions in Asthma

To the Editor: Wechsler et al. (July 14 issue) 1 describe self-reported outcomes of albuterol treatment as compared with placebo in patients with mild-to-moderate asthma. One possible explanation for the lack of incremental benefit with respect to these outcomes may be related to the experimental de...

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Published inThe New England journal of medicine Vol. 365; no. 15; pp. 1446 - 1448
Main Authors Rolla, Giovanni, Bucca, Caterina, Bibalo, Cristina, Panontin, Elisa, Longo, Giorgio, Straumann, Alex, Safroneeva, Ekaterina, Schoepfer, Alain M, Wechsler, Michael E, Kelley, John M, Kaptchuk, Ted J, Moerman, Daniel E
Format Journal Article
LanguageEnglish
Published United States Massachusetts Medical Society 13.10.2011
Subjects
Acupuncture Therapy
Airway management
Albuterol - therapeutic use
Asthma
Asthma - therapy
Bronchodilator Agents - therapeutic use
Female
Humans
Male
Patients
Placebo Effect
Placebos - therapeutic use
Respiratory tract
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Summary:To the Editor: Wechsler et al. (July 14 issue) 1 describe self-reported outcomes of albuterol treatment as compared with placebo in patients with mild-to-moderate asthma. One possible explanation for the lack of incremental benefit with respect to these outcomes may be related to the experimental design of the study. The benefit of the bronchodilator effect of albuterol could have not been appreciated by patients who were probably asymptomatic and had baseline mild airway obstruction, particularly because they were evaluated under resting conditions for 2 hours in a hospital setting. More information could have been obtained about subjective outcomes by allowing the . . .
Bibliography:SourceType-Other Sources-1
content type line 63
ObjectType-Correspondence-1
ObjectType-Commentary-2
ISSN:0028-4793
1533-4406
DOI:10.1056/NEJMc1109235