Brachial-Ankle Pulse Wave Velocity is Associated with the Risk of New Carotid Plaque Formation: Data from a Chinese Community-based Cohort

• Published in: Scientific reports Vol. 8; no. 1; pp. 7037 - 7
• Main Authors: Yang, Yao, Fan, Fangfang, Kou, Minghao, Yang, Ying, Cheng, Guanliang, Jia, Jia, Gao, Lan, Zhou, Zechen, Chen, Dafang, Zhang, Yan, Huo, Yong
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 04.05.2018; Nature Publishing Group; Nature Portfolio
• Subjects: 692/699/75/593/2100; 692/699/75/593/2724; 692/700/478/174; Alcohol use; Ankle; Antihypertensives; Arteriosclerosis; Atherosclerosis; Blood pressure; Body mass index; Cardiovascular disease; Cardiovascular diseases; Cholesterol; Creatinine; Diabetes; Heart rate; Humanities and Social Sciences; Hypertension; Lipids; Lipoproteins; Medicine; multidisciplinary; Plaques; Population; Population studies; Risk factors; Science; Science (multidisciplinary); Tobacco; Triglycerides; Velocity; Wave velocity
• ISSN: 2045-2322; 2045-2322
• DOI: 10.1038/s41598-018-25579-2

Artery stiffness is an independent marker for atherosclerotic cardiovascular diseases. However, whether the brachial-ankle pulse wave velocity (ba-PWV) is related to new carotid plaque formation is unresolved. This study aimed to investigate the association between baseline ba-PWV and new carotid plaque formation in a Chinese community-based population without carotid plaques at baseline. This study population consisted of a total of 738 participants from an atherosclerosis cohort in Beijing, China. After a mean 2.3-year follow-up, the incidence of carotid plaques were 21.2% and 36.5% in the groups with ba-PWV < 1,400 cm/s and ≥1,400 cm/s, respectively. Compared with baseline ba-PWV < 1,400 cm/s group, ba-PWV ≥ 1,400 cm/s group was significantly associated with the incidence of new carotid plaque formation (odds ratio [OR] = 2.14, 95% CI: 1.50–3.03, P < 0.01), even after adjusting for common risk factors (OR = 1.52, 95% CI: 1.02–2.25, P = 0.04). Furthermore, there was a strong relationship between baseline ba-PWV and carotid plaque formation in subjects with ba-PWV < 1,400 cm/s, but no such relationship was found in subjects with baseline ba-PWV ≥ 1,400 cm/s. In conclusion, this study suggests that baseline ba-PWV is independently associated with the risk of carotid plaque formation in a Chinese community-based population.